In an evaluation of medicines approved by the European Medicines Agency 2000 to 2010, Ruben Duijnhoven and colleagues find that the number of patients evaluated for medicines approved for chronic use are inadequate for evaluation of safety or long-term efficacy.

Cement manufacturing is a major source of greenhouse gases. But cutting emissions means mastering one of the most complex materials known.

The quality of reporting of animal studies lags behind that of human randomized controlled trials but a series of additions to the ARRIVE guidelines will help ensure that the standards are comparable.

Non-communicable diseases (NCDs, e.g., cardiovascular disease, diabetes, cancers, chronic respiratory diseases, neurological diseases) have been the commonest cause of death and disability globally for at least the last three decades. Even in sub-Saharan Africa, NCDs contribute a third of the disability-adjusted life year burden. However, research resources allocated to NCDs in low- and middle-income countries (LMICs) are trivial.