Nobel Prize
Nobel Prize in Physiology or Medicine 2012
2012-10-08
The Nobel Prize recognizes two scientists who discovered that mature, specialised cells can be reprogrammed to become immature cells capable of developing into all tissues of the body. Their findings have revolutionised our understanding of how cells and organisms develop.
Sir John B. Gurdon |
Born: 1933, Dippenhall, United Kingdom Affiliation at the time of the award: Gurdon Institute, Cambridge, United Kingdom Prize motivation: "for the discovery that mature cells can be reprogrammed to become pluripotent Publications: The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. Histone variant macroH2A confers resistance to nuclear reprogramming. Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process? |
Born: 1962 Affiliation at the time of the award: Kyoto University, Kyoto, Japan, Gladstone Institute, San Francisco, CA, USA Prize motivation: "for the discovery that mature cells can be reprogrammed to become pluripotent" Publications: Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discoveryInduction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells |
Shinya Yamanaka |
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