MicroRNA expression in response to controlled exposure to diesel exhaust: Attenuation by the antioxidant n-acetylcysteine in a randomized crossover study
Health effects associated with diesel exhaust (DE) are thought to be mediated in part by oxidative stress, but the detailed mechanisms therein are largely unknown. MicroRNAs (miRNAs) regulate gene expression posttranscriptionally and may respond to exposures such as DE. The researchers profiled peripheral blood cellular miRNAs in mild asthmatic participants exposed to controlled DE with and without antioxidant supplementation.