Keeping phase III tuberculosis trials relevant: Adapting to a rapidly changing landscape

One of the first multicenter randomized trials was the British Medical Research Council (MRC) streptomycin trial. From the first meeting of the special committee to “plan trials of streptomycin in tuberculosis” in September, 1946, the primary trial results from 107 participants followed for 12 months were published in the British Medical Journal two years later in October, 1948. Although treatment with a single drug was subsequently shown to be inadequate because of the generation of drug resistance, the results of the trial changed clinical practice.

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