Feedback regulation of Arid5a and Ppar-γ2 maintains adipose tissue homeostasis
Obesity is now considered an epidemic problem worldwide. To develop effective interventions against obesity, we need to understand precisely the regulatory mechanism of adipogenesis, a process of forming adipocytes from fibroblast cells.
In this study, the researchers revealed that the Arid5a protein regulates the adipogenesis and the development of obesity in mice. Arid5a inhibits adipogenesis by suppressing the transcription of peroxisome proliferator activated receptor gamma 2 (Ppar-γ2), which is the main facilitator of adipogenesis.