BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity
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09/01/2018
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Cell Host & Microbe
The tuberculosis vaccine bacillus Calmette-Guérin (BCG) has heterologous beneficial effects against non-related infections.
The basis of these effects has been poorly explored in humans. In a randomized placebo-controlled human challenge study, we found that BCG vaccination induced genome-wide epigenetic reprograming of monocytes and protected against experimental infection with an attenuated yellow fever virus vaccine strain.