Inorganic arsenic related changes in the stromal tumor microenvironment in a prostate cancer cell–conditioned media model
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19/11/2015
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Environmental Health Perspectives
The tumor microenvironment plays in an important role in the progression of cancer by mediating stromal-epithelial paracrine signaling, which can aberrantly modulate cellular proliferation and tumorigenesis. Exposure to environmental toxicants, such as inorganic arsenic (iAs), has also been implicated in the progression of prostate cancer.