The quality restoration of any river, especially of the Yamuna at Mathura, a religious center in India, is a very complex and interdisciplinary endeavor. River pollution cannot be minimized merely by diverting the routes of drains carrying wastewaters and/or establishing sewage treatment plants. The required strategy for pollution control should not only be a multi-line approach but also be fool proof. The various sources of pollution in the Yamuna river and possible strategies to restore this ailing river to its pristine status are presented in this paper.