Medical Research

Order of the National Green Tribunal regarding deterioration of Nayar river, Uttarakhand, 05/06/2025

Order of the National Green Tribunal in the matter of In Re: News Item titled "Nayar river is vanishing - a yatra reveals conservation goes beyond science and policy" appearing in ‘The Down To Earth’ dated 03.06.2025. The original application was registered suo-motu based on the news item titled "Nayar …

Daclatasvir plus Sofosbuvir for HCV in patients coinfected with HIV-1

The combination of daclatasvir, a hepatitis C virus (HCV) NS5A inhibitor, and the NS5B inhibitor sofosbuvir has shown efficacy in patients with HCV monoinfection. Data are lacking on the efficacy and safety of this combination in patients coinfected with human immunodeficiency virus type 1 (HIV-1). Original Source

Studies show success in HIV drugs for prevention

Despite evidence that taking powerful anti-HIV drugs can help protect uninfected partners from contracting the virus that causes AIDS, the therapy is far from becoming routinely prescribed, scientists said Monday. The practice, known as pre-exposure prophylaxis, or PrEP, means that a healthy person who engages in sex with an HIV-positive …

Africa: Two New Trials of Ebola Vaccines Begin in Europe, Africa

Two new Ebola vaccine trials began on Wednesday with volunteers in Britain, France and Senegal getting "prime-boost" immunisations developed by Bavarian Nordic, GlaxoSmithKline and Johnson & Johnson. The mid-stage, or Phase II, trials are designed primarily to test the vaccines' safety, but will also assess whether they provoke an immune …

Nigeria: Inhalable Ebola Vaccine Discovered

Researchers at the University of Texas Medical Branch (UTMB), Galveston have discovered an inhalable vaccine that can protect rhesus macaque monkeys against severe illness and death when they were exposed to the Ebola virus. Rhesus Macaques are among the most widespread primates after humans and are the monkeys most widely …

Researchers develop aerosolized vaccine that protects primates against Ebola

A collaborative team from The University of Texas Medical Branch at Galveston and the National Institutes of Health have developed an inhalable vaccine that protects primates against Ebola. The findings were recently published in the Journal of Clinical Investigation. Previous studies with primates suggest that aerosols of most biothreat agents, …

Critical' lapses in clinical trials of TN research firm

Clinical trials in India have again come under the regulatory scanner after the World Health Organisation (WHO) pointed out “critical“ lapses in trials of HIV drugs being conducted by a Chennaibased research organization. Following the enforcement by the United Nations' agency, the Indian regulator, Drugs Controller General of India (DCGI), …

HIV Protein Structure Unraveled by Scientists: New Treatments Possible

Scientists may have managed to unravel the elusive structure of the HIV protein. This could lead to new findings in terms of threatening this immunodeficiency virus, which could help patients across the world. HIV is a retrovirus that leads to acquired immunodeficiency syndrome, or AIDS. Globally, about 35 million people …

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, …

The efficacy and safety of the RTS,S/AS01 candidate malaria vaccine during 18 months of follow-up have been published previously. Herein, we report the final results from the same trial, including the efficacy of a booster dose.

The 21st century Cures Act — Will it take us back in time?

In May 2015, the 21st Century Cures Act was introduced in the U.S. House of Representatives, with the goal of promoting the development and speeding the approval of new drugs and devices.1 Championed by the pharmaceutical, biotechnology, and device industries, the bill was approved unanimously (51 to 0) in committee …

Zimbabwe: Zim to Start HIV Vaccine Trials

Zimbabweans may soon be immunised against HIV transmission if trials for a vaccine to prevent the spread of the deadly virus expected to start in the near future are successful. The trial will also be carried out in Zambia and Malawi, as Southern Africa steps up efforts to fight HIV. …

Is cancer hiding in your home?

A staggering range of commonly used chemicals ­ from insecticides to plastic additives to some common medications ­used even in very low quantities are likely to cause cancer. This was the conclusion reached by a massive study involving 174 scientists from 28 countries -including India --who researched the chemical actions …

Smoking parents can turn toddlers into fat children, claims new study

Children whose parents smoked when they were toddlers are likely to have a wider waist and a higher body mass index (BMI) by the time they reach the age of 10 years, a new study has found. Researchers at the University of Montreal and its affiliated CHU Sainte Justine Research …

Australia chemists launches global hunt for new antibiotics to combat superbugs

SYDNEY, June 19 (Xinhua) -- Australian chemists have launched a global search to find antibiotics to combat superbug bacteria that are resistant to current antibiotics. The Queensland University bioscience researchers will use a 3.1 million Australian dollar (2.41 U.S. dollars) grant from the London-based medical charity Wellcome Trust to individually …

Successes and challenges on the road to cure Hepatitis C

Hepatitis C virus (HCV) represents a significant health burden worldwide, with an estimated 185 million people chronically infected. A leading cause of liver transplantation, HCV infection can result in severe liver disease including cirrhosis and hepatocellular carcinoma. Cure of HCV infection results in substantial decreases in such liver-related morbidity and …

Uncomfortable reality: 14% of urban India hit by constipation

In Some Cases, It May Lead To Strokes: Study. Piku's father Bhaskor Banerjee, in the latest Shoojit Sircar flick, suffers from severe constipation. As it turns out Mr Banerjee's problem is representative of a disturbing trend. 14% of India's urban population suffers from chronic bowel movement, an inability to pass …

China, US develop new MERS treatment

SHANGHAI - Chinese and American scientists have jointly developed a new antibody targeting the Middle East Respiratory Syndrome (MERS) virus, which has killed 16 people and landed 150 others in hospital. Fudan University, which worked with US National Institutes of Health to develop the antibody, said on Monday that tests …

Experimental Drug Regrows Damaged Body Tissue

An experimental drug treatment has opened a new door in regenerative medicine by helping lab mice regrow damaged liver, colon and bone marrow tissue, US researchers said Thursday. If the therapy is found to work in humans, scientists say it may save the lives of people who are critically ill …

Ghana Says Locals Used As 'Guinea Pigs' in Ebola Trial

Ghana has suspended a trial for an Ebola vaccine after complaints that locals were being needlessly used as "guinea pigs" in a country currently free of the deadly disease. A spokesman for the West African nation's health minister told a local radio station on Wednesday that many Ghanaians had contacted …

Dietary sodium suppresses digestive efficiency via the renin-angiotensin system

Dietary fats and sodium are both palatable and are hypothesized to synergistically contribute to ingestive behavior and thereby obesity. Contrary to this hypothesis, C57BL/6J mice fed a 45% high fat diet exhibited weight gain that was inhibited by increased dietary sodium content. This suppressive effect of dietary sodium upon weight …

Peto’s paradox and the hallmarks of cancer: constructing an evolutionary framework for understanding the incidence of cancer

An evolutionary perspective can help unify disparate observations and make testable predictions. We consider an evolutionary model in relation to two mechanistic frameworks of cancer biology: multistage carcinogenesis and the hallmarks of cancer. The multistage model predicts that cancer risk increases with body size and longevity; however, this is not …

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