Medical Research

Order of the National Green Tribunal regarding deterioration of Nayar river, Uttarakhand, 05/06/2025

Order of the National Green Tribunal in the matter of In Re: News Item titled "Nayar river is vanishing - a yatra reveals conservation goes beyond science and policy" appearing in ‘The Down To Earth’ dated 03.06.2025. The original application was registered suo-motu based on the news item titled "Nayar …

Lung Cancer Genomic Mapping Yields New Targets in Study

Mutations within a small cluster of genes tied to tumor growth are involved in three-quarters of the cases of the most common form of lung cancer, according to a study that could help link treatment to specific genetic flaws. The research is the most comprehensive genomic analysis of adenocarcinoma, a …

Malaria parasite 'gets down to the bone'

Parasites infected with malaria can hide inside the bone marrow and evade the body's defences, research confirms. The discovery could lead to new drugs or vaccines to block transmission. The research, published in Science Translational Medicine, fills a "key knowledge gap" in the biology of the disease, say scientists at …

DCGI Wants Pharma Cos to Share Clinical Trial Benefits with India

Wants cos to ensure early launch of new therapies here if trials prove successful This move is part of steps DCGI has taken last week to bring clarity in the clinical trials space and ensure patients are not exploited Multinational pharmaceutical companies keen to conduct clinical trials for new drugs …

U.S.-based Japanese scientist makes potent version of H1N1 flu

A U.S.-based Japanese scientist said Wednesday he has succeeded in engineering a version of the so-called swine flu virus that would be able to evade the human immune system. The research on the 2009 H1N1 virus at a high-security lab at the University of Wisconsin, Madison has not yet been …

Procedure for review of application of CT and new drugs

Procedure for review of application of CT and New drugs - Office Order dated 03.07.2014.

Malaria makes you smell delicious to mosquitoes

Malaria may alter the way people smell to make them more alluring to mosquitoes, according to a new finding that can help detect the deadly disease non-invasively through body odour. An infection with malaria pathogens changes the scent of infected mice, making those infected more attractive to mosquitoes, researchers have …

Risk of cardiovascular disease among postmenopausal women with prior pregnancy loss: The Women’s Health Initiative

Metabolic, hormonal, and hemostatic changes associated with pregnancy loss (stillbirth and miscarriage) may contribute to the development of cardiovascular disease (CVD) in adulthood. This study evaluated prospectively the association between a history of pregnancy loss and CVD in a cohort of postmenopausal women.

Evidence for camel-to-human transmission of MERS Coronavirus

We describe the isolation and sequencing of Middle East respiratory syndrome coronavirus (MERS-CoV) obtained from a dromedary camel and from a patient who died of laboratory-confirmed MERS-CoV infection after close contact with camels that had rhinorrhea. Nasal swabs collected from the patient and from one of his nine camels were …

Team science and the creation of a novel rotavirus vaccine in India: a new framework for vaccine development

In The Lancet, findings from Nita Bhandari and colleagues' phase 3 clinical trial1 show the safety and efficacy of the 116E rotavirus vaccine against severe rotavirus gastroenteritis in Indian infants. The vaccine has an efficacy similar to that of two licensed oral rotavirus vaccines—RotaTeq (Merck) and Rotarix (GlaxoSmithKline)—when tested in …

Rare gene flaws can cut heart disease risk by 40%

Hope Hinges On Drugs Mimicking Effects Of Mutations That Cripple APOC3 Four rare mutations in a single gene may reduce the risk of heart disease by 40%, a new study has found. By scouring the DNA of thousands of patients, researchers at the Broad Institute, Massachusetts General Hospital, and their …

HIV trial attacked

Critics question ethics of allowing pregnant women to receive treatment that falls below the standard in their country.

Skin β-Endorphin mediates addiction to UV light

UV light is an established carcinogen, yet evidence suggests that UV-seeking behavior has addictive features. Following UV exposure, epidermal keratinocytes synthesize proopiomelanocortin (POMC) that is processed to melanocyte-stimulating hormone, inducing tanning. We show that, in rodents, another POMC-derived peptide, β-endorphin, is coordinately synthesized in skin, elevating plasma levels after low-dose …

The UK Medical Innovation Bill: hype and hope

On June 5, the advertising magnate Maurice Saatchi reintroduced the Medical Innovation Bill into the UK House of Lords. Anguished and angered by the lack of effective treatment for his wife, who died from ovarian cancer 3 years ago, the Bill aims to protect doctors from litigation should they choose …

China launches national human proteome project

China has launched a country-specific human proteome project, a genome decoding initiative expected to bring forward new methods to prevent and treat major endemic diseases. The Beijing-based Academy of Military Medical Sciences held a meeting on Tuesday to arrange research work, marking the official launch of the China Human Proteome …

Drug makers seek out-of-court settlement in clinical trial cases

According to the drug regulator's website, merely 25 clinical trials have been approved by the DCGI in the first five months of 2014 In order to keep pace with the government's healthcare agenda, the pharmaceutical sector wants research work to go on, at any cost. In a letter to health …

Efficacy of Pneumococcal Nontypable Haemophilus influenzae Protein D Conjugate Vaccine (PHiD-CV) in Young Latin American children: A double-blind randomized controlled trial

In a double-blind randomized controlled trial, Xavier Saez-Llorens and colleagues examine the vaccine efficacy of PHiD-CV against community-acquired pneumonia in young children in Panama, Argentina, and Colombia.

‘Obesity in kids up 47%, adults 28%’

In a startling revelation, a new study has found significant increase in rates of obesity and overweight in both adults (28 per cent increase) and children (up by 47 per cent) in the past 33 years, with the number of overweight and obese people rising from 857 million in 1980 …

HealthMin fixes relief for clinical trial errors

Companies conducting clinical trials in India will not be able to get away in case any untoward incident happens. According to the Union health ministry, the quantum of compensation in case of 100 per cent disability should be 80 per cent of the compensation which would have been due for …

Are we there yet? The smallpox research agenda using Variola Virus

Despite significant advances, there is more work to be done before the international community can be confident that it possesses sufficient protection against any future smallpox threats. The current World Health Organization (WHO)-approved research agenda for smallpox has been tightly focused by the interpretation that research “essential for public health” …

Draft formula to determine the quantum of compensation in case of clinical trial related injury (other than death)

The Drugs and Cosmetics Rules, 1945 provides under Rule 122DAB that in the case of clinical trial related injury/death, the trial subject is entitled for the financial compensation. A committee was constituted under the Chairmanship of Shri R. K. Jain, AS & DG to deliberate and work out formula to …

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