This analysis estimates the number of charging points and hydrogen refueling stations needed to enable the transition to 100 percent sales of zero-emission Class 7 and Class 8 tractor-trailers by 2040 in the United States. By 2030, approximately 127,000 charging points and 220 hydrogen refueling stations will be necessary to support a fleet of 103,000 zero-emission tractor-trailers. The cumulative investment needed to install publicly available infrastructure is $6.4 billion, beginning in 2021. Of 32,000 publicly accessible chargers, 14,000 will require a charging speed of 350 kW or greater.