Brain health is a rapidly expanding field. WHO’s position paper on optimizing brain health across the life course is a technical complement to the recently-adopted Intersectoral global action plan on epilepsy and other neurological disorders 2022–2031. Many determinants are known to affect brain health at different stages of life. The …
Brain health is a rapidly expanding field. WHO’s position paper on optimizing brain health across the life course is a technical complement to the recently-adopted Intersectoral global action plan on epilepsy and other neurological disorders 2022–2031. Many determinants are known to affect brain health at different stages of life. The …
Epilepsy in children is the mostfrequent, heterogeneous and difcultto classify chronic neurologic condition with the etiology found in 35–40% of patients.Our aim is to detectthe metabolic diferences between the epileptic children and the children with no neurological abnormalities in orderto defne the metabolic background fortherapy monitoring.The studied group included 28 …
Acute flaccid myelitis (AFM) is a neurologic condition characterized by flaccid limb weakness. After a large number of reports of AFM in 2014, the Centers for Disease Control and Prevention began standardized surveillance in the United States to characterize the disease burden and explore potential etiologies and epidemiologic associations. Original …
Several small experimental studies and cross-sectional observational studies have shown that exposure to the natural environment might protect against attention-deficit hyperactivity disorder (ADHD) or moderate the symptoms of ADHD in children. The researchers aimed to assess whether exposure to the natural environment protects against ADHD and whether this hypothesised protective …
Working memory deficits are present in many neuropsychiatric diseases with diagnosis-related severity. However, it is unknown whether this common behavioral abnormality is a continuum explained by a neural mechanism shared across diseases or a set of discrete dysfunctions. Here, we performed predictive modeling to examine working memory ability (WMA) as …
Use of tobacco products is injurious to health in men and women. However, tobacco use by pregnant women receives greater scrutiny because it can also compromise the health of future generations. More men smoke cigarettes than women. Yet the impact of nicotine use by men upon their descendants has not …
On February 1, 2016, the World Health Organization declared that the cluster of microcephaly cases and other neurological disorders constitute public health emergency of international concern. Furthermore, few studies demonstrated that there was an increased evidence of causal relationship of Zika virus (ZIKAV) infection and microcephaly, birth abnormalities and neurological …
Prenatal exposure to organophosphate (OP) pesticides has been linked with poorer neurodevelopment and behaviors related to autism spectrum disorders (ASD) in previous studies, including in the Center for Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, a birth cohort living in the agricultural Salinas Valley in California. The …
Aggregation of alpha synuclein has strong implications in Parkinson’s disease. The heterogeneity of folding/aggregation landscape and transient nature of the early intermediates result in difculty in developing a successful therapeutic intervention. Here we used fuorescence measurements at ensemble and single molecule resolution to study how the late and early events …
The objective of the study was to investigate the kinetics and metabolism of caffeine in serum from patients with Parkinson disease (PD) and controls using liquid chromatography–mass spectrometry. Original Source
1991 Gulf War (GW) veterans continue to experience debilitating cognitive and mood problems more than two decades following their return from deployment. Suspected causes for these cognitive complaints include additive and/or synergistic effects of the varying combinations of exposures to chemicals in theater, including pesticides and pyridostigmine bromide (PB) pills. …
This landmark study published in Lancer finds that toxic air, water, soils and workplaces kill at least 9 millon people and cost trillions of dollars every year. Pollution kills more people in India than anywhere else in the world revealed the study. Pollution is the largest environmental cause of disease …
Maternal folic acid (FA) protects against developmental toxicity from certain environmental chemicals. The researchers examined combined exposures to maternal FA and pesticides in relation to autism spectrum disorder (ASD). Original Source
Natural environments, including green spaces, may have beneficial impacts on brain development. However, longitudinal evidence of an association between long-term exposure to green spaces and cognitive development (including attention) in children is limited. The researchers evaluated the association between lifelong residential exposure to green space and attention during preschool and …
Researchers describe long-term functional, neurodiagnostic, and psychosocial outcomes of a cohort of 12 children from Colorado diagnosed with acute flaccid myelitis (AFM) in 2014. Original Source
CYP1A1 gene is involved in estrogen metabolism, and previously, we have reported association of variant rs2606345 with altered anti-epileptic drugs (AED) response in North Indian women with epilepsy (WWE). The present study aims to replicate the pharmacogenetic association, perform functional characterization and study its distribution within ethnically diverse Indian population. …
The molecular underpinnings of the dissociation of cognitive performance and neuropathological burden are poorly understood, and there are currently no known genetic or epigenetic determinants of the dissociation. Original Source
For the first time a “tipping point” molecular link between the blood sugar glucose and Alzheimer’s disease has been established by scientists, who have shown that excess glucose damages a vital enzyme involved with inflammation response to the early stages of Alzheimer’s. Abnormally high blood sugar levels, or hyperglycaemia, is …
The English and Romanian Adoptees study is a longitudinal, natural experiment investigation into the long-term outcomes of individuals who spent from soon after birth to up to 43 months in severe deprivation in Romanian institutions before being adopted into the UK. We used developmentally appropriate standard questionnaires, interviews completed by …
Brain and cognitive development during the first 1000 days from conception are affected by multiple biomedical and socioenvironmental determinants including nutrition, health, nurturing, and stimulation. An improved understanding of the long-term influence of these factors is needed to prioritise public health investments to optimise human development. Original Source
