Order of the Supreme Court of India in the matter of Network of People Living With HIV/AIDS & Others Vs Union of India & Others dated 24/02/2025. The Supreme Court (SC), February 24, 2025 has directed all states to file their affidavits addressing concerns raised about antiretroviral therapy (ART) drugs …
To ensure availability of specialist doctors at the secondary and tertiary levels, the Centre today announced the creation of additional 5,000 post- graduate (PG) seats every year even as it increased the budget allocation for the health sector by almost 28 per cent. The government also announced setting up of …
HIV positivity among the general population at testing centers in the city has also come down from 7.12% in 2008 to 0.81% in 2016. The prevalence of HIV/AIDS in Chandigarh, has reduced from 0.27% in 2008 to 0.11% in 2016, officials said on Wednesday. HIV positivity among the general population …
The patients had caught malaria when visiting Africa. A key malaria treatment has failed for the first time in patients being treated in the UK, doctors say. The drug combination was unable to cure four patients, who had all visited Africa, in early signs the parasite is evolving resistance. A …
Severe malaria is a life-threatening complication of an infection with the protozoan parasite Plasmodium falciparum, which requires immediate treatment. Safety and efficacy concerns with currently used drugs accentuate the need for new chemotherapeutic options against severe malaria. Here we describe a medicinal chemistry program starting from amicarbalide that led to …
The Ministry of Health and Family Welfare has notified Medical Devices Rules, 2017 on 31.01.2017. The new Rules have been framed in conformity with Global Harmonisation Task Force (GHTF) framework and conform to best international practices. Only 15 categories of medical devices are, at present, regulated as drugs and to …
Japanese encephalitis (JE) virus (JEV) causes severe epidemic encephalitis across Asia, for which the live attenuated vaccine SA14-14-2 is being used increasingly. JEV is a flavivirus, and is closely related to dengue virus (DENV), which is co-endemic in many parts of Asia, with clinically relevant interactions. There is no information …
In the wake of the recent death of an American woman after contracting an infection resistant to antibiotics, the drug regulator has directed the pharma supply chain, including retailers, chemists and drug makers, to strictly follow norms while selling antibiotics. The Drugs Controller General of India (DCGI) has also asked …
Kinase inhibitors are effective cancer therapies, but tumors frequently develop resistance. Current strategies to circumvent resistance target the same or parallel pathways. We report here that targeting a completely different process, autophagy, can overcome multiple BRAF inhibitor resistance mechanisms in brain tumors. BRAFV600Emutations occur in many pediatric brain tumors. We …
The Influenza A virus (IAV) is a major human pathogen that produces significant morbidity and mortality. To explore the contribution of alveolar macrophages (AlvMΦs) in regulating the severity of IAV infection we employed a murine model in which the Core Binding Factor Beta gene is conditionally disrupted in myeloid cells. …
The device enables researchers to visualise the micro environment and monitor how cells respond in real time to the drug. Scientists have developed a miniature lab device that could speed up the adoption of new anti-cancer treatments by showing which drugs perform the best against tumours. The small, versatile and …
Novel drug regimens are needed for tuberculosis (TB) treatment. New regimens aim to improve on characteristics such as duration, efficacy, and safety profile, but no single regimen is likely to be ideal in all respects. By linking these regimen characteristics to a novel regimen’s ability to reduce TB incidence and …
During November–December 2015, as part of the 2015 cholera outbreak response in Iraq, the Iraqi Ministry of Health targeted ≈255,000 displaced persons >1 year of age with 2 doses of oral cholera vaccine (OCV). All persons who received vaccines were living in selected refugee camps, internally displaced persons camps, and …
Antibiotic-resistant bacterial infections are on the rise and pose a serious threat to society. The influence of genetic resistance mechanisms on antibiotic therapy is well described. However, other factors, such as epigenetic resistance or the impact of the environment on antibiotic therapy, are less well understood. Here, we describe and …
rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus. We tested the effect of rVSV-ZEBOV in preventing Ebola virus disease in contacts and contacts of contacts of recently confirmed cases in Guinea, west Africa. Original Source
The World Malaria Report 2016 summarizes information received from malaria-endemic countries and other sources, and updates the analyses presented in the 2015 report. The World Malaria Report is WHO’s flagship malaria publication, released each year in December. It assesses global and regional malaria trends, highlights progress towards global targets, and …
Poor-quality medicines present a serious public health problem, particularly in emerging economies and developing countries, and may have a significant impact on the national clinical and economic burden. Attention has largely focused on the increasing availability of deliberately falsified drugs, but substandard medicines are also reaching patients because of poor …
Scientists at The Scripps Research Institute (TSRI) in the US have developed a vaccine that appears to decrease the risk of fatal opioid overdose. The vaccine blocks the pain-numbing effects of the opioid drugs oxycodone (oxy) and hydrocodone (hydro) in animal models, said the study published online in the journal …
Australian scientists have taken a step in the "right direction" to creating a vaccine for the deadly HIV virus. Researchers from South Australia's University of Adelaide and the Queen Elizabeth Hospital have used a common cold virus to introduce their DNA-based vaccine into the immune system of laboratory mice, Xinhua …
An influenza pandemic remains a major public health concern. A key strategy to prevent a pandemic is to stockpile and pre-position stable influenza vaccine to allow rapid deployment in response to an outbreak. However, most influenza vaccines today are formulated as liquids that are stable only within a temperature range …
Environmental enteropathy (EE) is a poorly understood condition that refers to chronic alterations in intestinal permeability, absorption, and inflammation, which mainly affects young children in resource-limited settings. Recently, EE has been linked to suboptimal oral vaccine responses in children, although immunological mechanisms are poorly defined. The objective of this study …
