Drugs

Order of the Supreme Court regarding ART drugs for people living with HIV/AIDS, 24/02/2025

Order of the Supreme Court of India in the matter of Network of People Living With HIV/AIDS & Others Vs Union of India & Others dated 24/02/2025. The Supreme Court (SC), February 24, 2025 has directed all states to file their affidavits addressing concerns raised about antiretroviral therapy (ART) drugs …

India’s intellectual property-based biomedical start-ups

I have posed 50 questions each to the founders of 50 young Indian biomedical firms that are less than 5 years old. The questions were on the following themes: the backgrounds of the founders and their employees, the area of work of the company, its location and incubation experience, its …

Implementation of the malaria candidate vaccine RTS,S/AS01

As vaccine manufacturers tackle increasingly intractable pathogens, vaccines will be developed that show efficacy, but that are less efficacious than established vaccines. Consequently, regulatory and public health authorities will be faced with difficult decisions about whether such vaccines should be recommended for implementation and, if so, under what circumstances. The …

Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models

The phase 3 trial of the RTS,S/AS01 malaria vaccine candidate showed modest efficacy of the vaccine against Plasmodium falciparum malaria, but was not powered to assess mortality endpoints. Impact projections and cost-effectiveness estimates for longer timeframes than the trial follow-up and across a range of settings are needed to inform …

Brazil to fund development of vaccine for Zika virus

The Brazilian government announced it will direct funds to a biomedical research center to help develop a vaccine against a virus linked to brain damage in babies. Health Minister Marcelo Castro said Friday that the goal is for the Sao Paulo-based Butantan Institute to develop "in record time" a vaccine …

Diabetes drug may slow growth of pancreatic cancer: study

Researchers have uncovered a novel mechanism behind the ability of the diabetes drug metformin to inhibit the progression of pancreatic cancer. Researchers found that metformin decreases the inflammation and fibrosis characteristic of the most common form of pancreatic cancer. The findings indicate that this beneficial effect may be most prevalent …

Accuracy of coverage survey recall following an integrated mass drug administration for lymphatic filariasis, schistosomiasis, and soil-transmitted helminthiasis

Achieving target coverage levels for mass drug administration (MDA) is essential to elimination and control efforts for several neglected tropical diseases (NTD). To ensure program goals are met, coverage reported by drug distributors may be validated through household coverage surveys that rely on respondent recall. This is the first study …

Relationship between nonmedical prescription-Opioid use and Heroin use

The nonmedical use of prescription opioids is a major public health issue in the United States, both because of the overall high prevalence and because of marked increases in associated morbidity and mortality. In 2014, a total of 10.3 million persons reported using prescription opioids nonmedically (i.e., using medications that …

Alternatives to antibiotics—a pipeline portfolio review

Antibiotics have saved countless lives and enabled the development of modern medicine over the past 70 years. However, it is clear that the success of antibiotics might only have been temporary and we now expect a long-term and perhaps never-ending challenge to fi nd new therapies to combat antibiotic-resistant bacteria. …

Falling plasmodium knowlesi malaria death rate among adults despite rising incidence, Sabah, Malaysia, 2010–2014

Deaths from Plasmodium knowlesi malaria have been linked to delayed parenteral treatment. In Malaysia, early intravenous artesunate is now recommended for all severe malaria cases. Researchers describe P. knowlesi fatalities in Sabah, Malaysia, during 2012–2014 and report species-specific fatality rates based on 2010–2014 case notifications. Sixteen malaria-associated deaths (caused by …

Creating safer polio vaccine strains for the post-eradication era

While the goal of polio virus eradication is in sight, there are concerns about post-eradication manufacturing and stockpiling vaccine stores containing live virus that could escape and repopulate the environment. A study published on December 31st in PLOS Pathogens reports the generation of new vaccine strains that appear both effective …

Himachal plans to universalise healthcare

The Himachal Pradesh government is planning to set up a healthcare model which will run like a trust, fully funded by the money that patients would otherwise pay as out of pocket (OOP) expenses — money spent on purchase of medical care that is not reimbursed. Run as a trust, …

Drug-resistant TB cases up

Experts Seek Change In Policy Measures To Check Mortality There has been a 12% increase in the incidence of multi-drug-resistant tuberculosis (MDR-TB) in India since 2000, a new study has revealed. The study is based on a retrospective analysis of patient data at Sir Ganga Ram Hospital. Researchers have termed …

Diabetes drug can also be used to treat obesity: Experts

AHMEDABAD: Doctors have recently discovered that a drug that is currently being used to treat diabetes in adults can also be used on obese patients to reduce fat. The Endocrine Society of India at its annual conference, `ESICON-2015', has unveiled new findings on obesity and ways of treating it. Dr …

Mers vaccine 'a step closer', say scientists

An effective vaccine to protect against the Mers virus is a step closer, a report in the journal Science suggests. European scientists genetically modified a version of the smallpox vaccine to display Mers virus protein on its surface. The vaccine was able to protect camels - the animal reservoir for …

Nigeria: Health Act to Release N50 Billion Annually

The National Health Act which is yet to be popular among Nigerians, and which is expected to encompass all health-related issues is to release about N50 billion annually. This can save the lives of 3,131,510 mothers, newborns and under 5s by 2022 and thus support Nigeria's response to poor indices. …

Strategies for early vaccination during novel influenza outbreaks

Ongoing research and technology developments hold the promise of rapid production and large-scale deployment of strain-specific or cross-protective vaccines for novel influenza viruses. We sought to investigate the impact of early vaccination on age-specific attack rates and evaluate the outcomes of different vaccination strategies that are influenced by the level …

That silver foil on your sweet may be toxic aluminium

Hyderabad: With Christmas and New Year festivities around the corner, people are going to indulge their sweet tooth and demand for sweetmeats will be on an all-time high. However, food safety officers (FSOs) in the city, who are waging a battle against adulterated, vegetables, fruits and dairy products, now warn …

World's first ibuprofen patch developed delivering pain relief directly to the skin

The world's first ibuprofen patch, which delivers pain relief directly to the skin, has been developed by researchers from the University of Warwick. The patch contains significant amounts of the drug, and is the only one of its kind that consistently delivers the painkiller. Working with Medherant, the bioadhesives company, …

CSIR’s move to develop Indian Tamiflu ‘wrong’

Hyderabad: The CAG has exposed the Council of Scientific Industrial Research’s hasty decision on a project for development of the Indian version of Tamiflu drug for bird flu that was to be developed with the help of Hyderabad-based IICT. After spending more than Rs 50 lakh, CSIR had shelved the …

World Malaria Report 2015

New estimates from WHO show a significant increase in the number of countries moving towards malaria elimination, with prevention efforts saving millions of dollars in healthcare costs over the past 14 years in many African countries. According to the "World Malaria Report 2015", more than half (57) of the 106 …

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