Medical Research

Order of the National Green Tribunal regarding deterioration of Nayar river, Uttarakhand, 05/06/2025

Order of the National Green Tribunal in the matter of In Re: News Item titled "Nayar river is vanishing - a yatra reveals conservation goes beyond science and policy" appearing in ‘The Down To Earth’ dated 03.06.2025. The original application was registered suo-motu based on the news item titled "Nayar …

Three Zika vaccines show promise in monkey studies: report

Three different experimental Zika vaccines being developed in the United States have worked well in monkey studies, paving the way for human trials in the coming months, researchers said Thursday. The report, published in the journal Science, comes as researchers rush to find a way to prevent the mosquito-borne virus, …

Obesity associated with increased brain-age from mid-life

Common mechanisms in aging and obesity are hypothesized to increase susceptibility to neurodegeneration, however direct evidence in support of this hypothesis is lacking. We therefore performed a cross-sectional analysis of MRI-based brain structure on a population-based cohort of healthy adults. Study participants were originally part of the Cambridge Centre for …

CMR lays down new rules for clinical trials and consent, applies them to traditional medicine

The SC had brought about such changes in trial laws after the HPV vaccine trial in 2009, funded by the Bill and Melinda Gates Foundation, where seven Adivasi girls who had been among the subjects administered the vaccine had died. After announcing the need to streamline clinical trial procedures in …

Human commensals producing a novel antibiotic impair pathogen colonization

The vast majority of systemic bacterial infections are caused by facultative, often antibiotic-resistant, pathogens colonizing human body surfaces. Nasal carriage of Staphylococcus aureus predisposes to invasive infection, but the mechanisms that permit or interfere with pathogen colonization are largely unknown. Whereas soil microbes are known to compete by production of …

China's about to rewrite human DNA using a revolutionary tool for the first time

Next month, Chinese researchers will edit adult human DNA using the revolutionary CRISPR/Cas-9 tool, commonly known as CRISPR, for the first time anywhere in the world. The researchers will attempt to cut faulty DNA out of the cells of lung cancer patients who have failed to respond to all other …

Brain map carves cortex into twice as many areas

Both brain activity and its physical properties were used to create the map A new brain map, based on multiple scans of more than 400 individuals, has carved the "cortex" into 180 different compartments - 97 of which are new. This crumpled outer layer of the brain is home to …

Stop the privatization of health data

Tech giants moving into health may widen inequalities and harm research, unless people can access and share their data, warn John T. Wilbanks and Eric J. Topol. Original Source

Scientists call for replacement of animals in antibody production

Routine scientific procedures using millions of animals are still being authorised when there is a tried and tested alternative, according to a group of scientists investigating the production of antibodies. The scientists, writing in the Cell Press journal, Trends in Biotechnology, say the use of animals in consumer society is …

Death rate slows, but 39 mn still HIV positive

Some 2.5 million people are still becoming infected with HIV every year even as drugs have slashed the death rate and virus-carriers live longer than ever, a global AIDS study said on Tuesday. New infections have plateaued for the past 10 years after a steep dip from the peak rate …

Structural basis of Zika virus helicase in recognizing its substrates

The recent explosive outbreak of Zika virus (ZIKV) infection has been reported in South and Central America and the Caribbean. Neonatal microcephaly associated with ZIKV infection has already caused a public health emergency of international concern. No specific vaccines or drugs are currently available to treat ZIKV infection. The ZIKV …

Comparison of artesunate–mefloquine and artemether–lumefantrine fixed-dose combinations for treatment of uncomplicated Plasmodium falciparum malaria in children younger than 5 years in sub-Saharan Africa: a randomised, …

WHO recommends combinations of an artemisinin derivative plus an antimalarial drug of longer half-life as treatment options for uncomplicated Plasmodium falciparum infection. In Africa, artemether–lumefantrine is the most widely used artemisinin-based combination therapy, whereas artesunate–mefl oquine is used infrequently because of a perceived poor tolerance to mefl oquine. WHO recommends …

A new era for HIV

The country has developed the biggest programme of antiretroviral therapy in the world. Now scientists are exploring the long-term consequences of the drugs. Original Source

CD4+ T cells expressing PD-1, TIGIT and LAG-3 contribute to HIV persistence during ART

HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these cells may lead to novel therapeutic strategies to reduce the size of the HIV reservoir. We hypothesized that CD4+ T cells expressing immune checkpoint molecules would be …

Dengue virus NS1 disrupts the endothelial glycocalyx, leading to hyperpermeability

Dengue is the most prevalent arboviral disease in humans and a major public health problem worldwide. Systemic plasma leakage, leading to hypovolemic shock and potentially fatal complications, is a critical determinant of dengue severity. Recently, we and others described a novel pathogenic effect of secreted dengue virus (DENV) non-structural protein …

International collaboration to create new cancer models to accelerate research

An international project to develop a large, globally accessible bank of new cancer cell culture models for the research community launched today. The National Cancer Institute (NCI), part of the National Institutes of Health; Cancer Research UK, London, England; the Wellcome Trust Sanger Institute, Cambridge, England; and the foundation Hubrecht …

Top scientists outline research strategy in bid to develop AIDS cure

PARIS – Calling the AIDS epidemic “the most important global health challenge in modern history,” more than 50 top scientists pressed their case Monday for a drive to stop the killer disease in its tracks. Anchored by Nobel medicine laureate Francoise Barre-Sinoussi, the group unveiled an aggressive research strategy for …

Austrian researchers develop potential AIDS treatment breakthrough

Austrian researchers have developed a treatment that could spell a breakthrough in the treatment of AIDS, the Krone newspaper reported on Monday. The research duo of Thomas Szekeres, a human geneticist who also serves as President of the Vienna Medical Association, and Walter Jaeger, a pharmacist, said the arduous research …

AIDS epidemic "over" in Australia, scientists say

Australia's top scientists and health experts have declared that Acquired Immune Deficiency Syndrome (AIDS) is no longer a public health issue, with Australia joining the small number of countries worldwide to have successfully overcome the epidemic. The number of AIDS cases diagnosed now is so low that researchers from the …

Rare diseases need our attention

A large number of diseases have been grouped together as ‘rare diseases’, because we do not know much about them. There is no consensus on the definition of a rare disease. This is because, obtaining reliable statistical estimates of the frequency of occurrence of a rare event, such as prevalence …

SC notice to govt on Rotavac trials data

PIL Wants Info From Each Of 3 Centres The Supreme Court has issued notices to the health ministry , the department of biotechnology and the Christian Medical College, Vellore, on a public interest petition demanding that detailed data of clinical trials on anti-diarrhoea vaccine Rotavac be made public. The trials, …

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