Medical Research

Order of the National Green Tribunal regarding deterioration of Nayar river, Uttarakhand, 05/06/2025

Order of the National Green Tribunal in the matter of In Re: News Item titled "Nayar river is vanishing - a yatra reveals conservation goes beyond science and policy" appearing in ‘The Down To Earth’ dated 03.06.2025. The original application was registered suo-motu based on the news item titled "Nayar …

Air pollution linked to heightened risk of Type 2 diabetes in obese Latino children

Latino children who live in areas with higher levels of air pollution have a heightened risk of developing Type 2 diabetes, according to a new USC-led study. Scientists tracked children’s health and respective levels of residential air pollution for about 3.5 years before associating chronic unhealthy air exposure to a …

Paracetamol pills in Malaysia do not contain deadly virus, says Health Ministry

The Malaysian Health Ministry today shot down rumours circulating on social media that P/500 paracetamol tablets in Malaysia contain the ‘Machupo’ virus. Malaysia’s Health director-general Datuk Dr Noor Hisham Abdullah said, just like most viruses, the Machupo cannot live in dry environments such as in paracetamol tablets. “The Machupo virus …

Kiwi childhood obesity study finds low exercise rates, high screen time in overweight and obese Taranaki kids and teens

Kids and teens in a Kiwi study on the health risks associated with obesity in young people were less physically active and spent more time watching screens than nationally recommended guidelines. The 239 children in the study were assessed when they enrolled in a Taranaki community-based 12 month intervention programme …

'Tuberculosis-resistant' cattle developed in China

Cattle were one of the first animals to be cloned. Scientists in China say they have produced cloned cattle with increased resistance to bovine tuberculosis.Twenty calves were born, of which 11 survived for more than three months. Bovine TB is a risk to cattle in many countries, including parts of …

UTA materials scientist invents breath monitor to detect flu

Perena Gouma, a professor in the Materials Science and Engineering Department at The University of Texas at Arlington, has published an article in the journal Sensors that describes her invention of a hand-held breath monitor that can potentially detect the flu virus. The article, published in January 2017, explains in-depth …

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

Kinase inhibitors are effective cancer therapies, but tumors frequently develop resistance. Current strategies to circumvent resistance target the same or parallel pathways. We report here that targeting a completely different process, autophagy, can overcome multiple BRAF inhibitor resistance mechanisms in brain tumors. BRAFV600Emutations occur in many pediatric brain tumors. We …

Genetically-engineered mosquitoes give hope against dengue

In a first, researchers have genetically engineered mosquitoes that have an increased resistance to infection by the dengue virus. After decades of research and countless control attempts, dengue continues to infect an estimated 390 million people around the world each year. Now, researchers report that mosquitoes carrying dengue virus (DENV) …

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory disturbances. Although the mechanisms linking adiposity to associated clinical conditions are poorly understood, recent studies suggest that adiposity may influence DNA methylation, a …

Ebola experimental vaccine is highly effective, trial shows

Trials conducted in Guinea, one of the West African countries most affected by an outbreak of Ebola that ended this year, show it offers 100% protection. The vaccine is now being fast-tracked through regulatory approval. Manufacturer Merck says it will make 300,000 doses of the rVSV-ZEBOV vaccine available for future …

Scientists Reformulate HIV Vaccine, Major Trial In South Africa Strikes Hope

After decades of battling the growing number of Human Immunodeficiency Virus (HIV) infections across the globe, a new major HIV vaccine trial is set to start in South Africa. This historic trial promises hope for millions of people to be protected from the still incurable disease. The clinical trial, dubbed …

New HIV vaccine to be tested in South Africa

JOHANNESBURG – Scientists say a new vaccine against HIV, to be tested in a trial to be launched in South Africa this week, could be “the final nail in the coffin” for the disease if it is successful. Anthony Fauci, director of the U.S. government’s National Institute of Allergy and …

Possible boost for clinical research as Sun Pharma, ICMR join hands

Clinical research in India may soon get a much-needed boost. The Indian Council of Medical Research (ICMR) and drug maker Sun Pharma are in talks to create a structure to fund clinical programmes focused on diseases prevalent here. A joint working group under the existing ICMR-Sun Pharma partnership met on …

Scientists develop vaccine against opioid overdose

Scientists at The Scripps Research Institute (TSRI) in the US have developed a vaccine that appears to decrease the risk of fatal opioid overdose. The vaccine blocks the pain-numbing effects of the opioid drugs oxycodone (oxy) and hydrocodone (hydro) in animal models, said the study published online in the journal …

The mesentery: structure, function, and role in disease

Systematic study of the mesentery is now possible because of clarification of its structure. Although this area of science is in an early phase, important advances have already been made and opportunities uncovered. For example, distinctive anatomical and functional features have been revealed that justify designation of the mesentery as …

'Clinical trials for Ayurveda dengue drug in advanced stages'

Clinical trials for Ayurveda-based drug for dengue, jointly being carried out by the Indian Council of Medical Research and the Ministry of AYUSH, are in the "advanced stages" and presently its clinical safety and efficacy is being tested, senior officials today said. Central Council for Research in Ayurvedic Sciences (CCRAS), …

‘India a key player in developing vaccines’

Attesting India’s expanding role in fighting epidemics, Peter Piot, the co-discoverer of Ebola virus, said India is a key player in the global initiative to develop vaccines. Speaking to The Hindu during an interaction with researchers at the India Institute of Public Health in Hyderabad, Prof. Piot said India along …

Why India is struggling to introduce dengue vaccines

Dengue is a dangerous debilitating disease that occasionally kills people and has no known cure or treatment. Two vaccines against the dreaded disease - one foreign and one Indian - await regulatory clearances. A multi-national pharma giant seeks waiver for a large clinical trial to be done so that the …

World's first dengue vaccine approved in over 10 countries

World's first dengue vaccine now approved in 11 countries (Getty Images)World's first dengue vaccine now approved in 11 countries (Getty Images) Sanofi-Pasteur, the vaccines global business unit of Sanofi, announced today that the dengue vaccines have received approval in 14 countries. Recent approvals for Dengvaxia granted by health authorities are …

Repurposing clinically approved cephalosporins for tuberculosis therapy

While modern cephalosporins developed for broad spectrum antibacterial activities have never been pursued for tuberculosis (TB) therapy, we identified first generation cephalosporins having clinically relevant inhibitory concentrations, both alone and in synergistic drug combinations. Common chemical patterns required for activity against Mycobacterium tuberculosis were identified using structure-activity relationships (SAR) studies. …

A natural Anopheles-associated Penicillium chrysogenum enhances mosquito susceptibility to Plasmodium infection

Whereas studies have extensively examined the ability of bacteria to influence Plasmodium infection in the mosquito, the tripartite interactions between non-entomopathogenic fungi, mosquitoes, and Plasmodium parasites remain largely uncharacterized. Here we report the isolation of a common mosquito-associated ascomycete fungus, Penicillium chrysogenum, from the midgut of field-caught Anopheles mosquitoes. Although …

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