Diagnostic Methods

Order of the National Green Tribunal regarding dumping yard at Baliapanda, Puri district, Odisha, 24/03/2025

Order of the National Green Tribunal (Eastern Zone Bench, Kolkata) in the matter of Haripriya Patel Vs State of Odisha & Others dated 24/03/2025. The matter related to the dumping yard at Baliapanda which is situated 50-100 meter away from Puri sea beach and a few km away from Puri …

The value of confirmatory testing in early infant HIV diagnosis programmes in South Africa: A cost-effectiveness analysis

The specificity of nucleic acid amplification tests (NAATs) used for early infant diagnosis (EID) of HIV infection is <100%, leading some HIV-uninfected infants to be incorrectly identified as HIV-infected. The World Health Organization recommends that infants undergo a second NAAT to confirm any positive test result, but implementation is limited. …

Moscow declaration to end TB

The WHO Global Ministerial Conference “Ending TB in the Sustainable Development Era: A Multisectoral Response” aims to accelerate implementation of the WHO End TB Strategy - with immediate action addressing gaps in access to care and the MDR-TB crisis - in order to reach the End TB targets set by …

Assessing current temporal and space-time anomalies of disease incidence

Approaches used to early and accurately characterize epidemiologic patterns of disease incidence in a temporal and spatial series are becoming increasingly important. Cluster tests are generally designed for retrospective detection of epidemiologic anomalies in a temporal or space-time series. Timely identification of anomalies of disease or poisoning incidence during ongoing …

Fighting for breath - A call to action on childhood pneumonia

This report focuses on what is now the single biggest cause of child deaths through infectious disease. Pneumonia is a disease of poverty. Fatalities are concentrated in the world’s poorest countries. Within those countries it is the poorest and most disadvantaged children who face the greatest risks. This report shows …

Effectiveness of cervical screening after age 60 years according to screening history: Nationwide cohort study in Sweden

The relatively high incidence of cervical cancer in women at older ages is a continuing concern in countries with long-established cervical screening. Controversy remains on when and how to cease screening. Existing population-based studies on the effectiveness of cervical screening at older ages have not considered women’s screening history. We …

Nucleic acid amplification testing in Indian blood banks: A review with perspectives

Nucleic acid amplification testing (NAT) is restricted to a few blood banks in India since 2008. This review was directed toward understanding NAT yield in different parts of the country and prevalence in the NAT of different types of virus. Materials and Methods: English literature was searched from 1990 to …

The impact of the roll-out of rapid molecular diagnostic testing for tuberculosis on empirical treatment in Cape Town, South Africa

The objective of the study was to investigate the impact of introducing a rapid test as the first-line diagnostic test for drug-sensitive tuberculosis in Cape Town, South Africa. Original Source

Cathepsin L and B as potential markers for liver fibrosis: Insights from patients and experimental models

Cathepsin L (CTSL) and B (CTSB) have a crucial role in extracellular matrix (ECM) degradation and tissue remodeling, which is a prominent feature of fibrogenesis. The aim of this study was to determine the role and clinical significance of these cathepsins in liver fibrosis. Original Source

National policy for treatment of rare diseases

A rare disease is a health condition of particularly low prevalence that affects a small number of people compared with other prevalent diseases in the general population. India, like many other developing countries, currently has no standard definition of rare diseases and since there is no epidemmiological data, there are …

Issues raised by the incidence and survival of childhood cancers

An Article by Audrey Bonaventure and colleagues in the Lancet Haematology provides international comparisons of 5-year net survival statistics of children diagnosed with leukaemia, and another Article by Eva Steliarova-Foucher and colleagues in the Lancet Oncology is an exhaustive report on worldwide incidence rates of childhood cancers observed in 2001–10. …

Development of a simple noninvasive model to predict significant fibrosis in patients with chronic Hepatitis B: Combination of ultrasound elastography, serum biomarkers, and individual characteristics

The accurate assessment of liver fibrosis is clinically important in patients with chronic hepatitis B (CHB). Blood tests and elastography are now widely used for the noninvasive diagnosis of liver fibrosis in CHB patients. The aim of this study was to develop a new and more accurate predictive model, which …

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis remains out of control in several parts of the world including Africa and Asia. Although tuberculosis control has been effective in some regions of the world, these gains are threatened by the increasing burden of multidrug-resistant (MDR) and …

Characteristics and survival of patients with Ebola virus infection, malaria, or both in Sierra Leone: a retrospective cohort study

The 2014–15 Ebola virus disease (EVD) epidemic strained health systems in west Africa already overburdened with other diseases, including malaria. Because EVD and malaria can be difficult to distinguish clinically, and rapid testing was not available in many Ebola Treatment Units (ETUs), guidelines recommended empirical malaria treatment. Little is known, …

Peer-led active tuberculosis case-finding among people living with HIV: lessons from Nepal

People living with a human immunodeficiency virus (HIV) infection have a high risk of tuberculosis and should undergo regular screening. However, they can be difficult to reach because they are stigmatized and discriminated against. Original Source

Investments in research and surveillance are needed to go beyond elimination and stop transmission of Leishmania in the Indian subcontinent

Progress towards the elimination of a neglected tropical disease from a country can sometimes be a curse, especially when policymakers are confronted with competing needs and priorities. This could mistakenly be interpreted as though the disease has been eradicated, resulting in the limited resources becoming redirected to the next priority, …

Worldwide increase of obesity is related to the reduced opportunity for natural selection

Worldwide rise of obesity may be partly related to the relaxation of natural selection in the last few generations. Accumulation of mutations affecting metabolism towards excessive fat deposition is suggested to be a result of less purging selection. Using the WHO and UN data for 159 countries there is a …

Epidemiology of human Anthrax in China, 1955−2014

Using national surveillance data for 120,111 human anthrax cases recorded during 1955−2014, we analyzed the temporal, seasonal, geographic, and demographic distribution of this disease in China. After 1978, incidence decreased until 2013, when it reached a low of 0.014 cases/100,000 population. The case-fatality rate, cumulatively 3.6% during the study period, …

Assay optimization for molecular detection of Zika virus

The objective of the study was to examine the diagnostic performance of real-time reverse transcription (RT)-polymerase chain reaction (PCR) assays for Zika virus detection. Original Source

Order of the Supreme Court of India regarding search engines advertising/hosting pre-natal sex determination ads, 16/11/2016

Order of the Supreme Court of India in the matter of Sabu Mathew George Vs Union of India & Others dated 16/11/2016 regarding search engines advertising/hosting pre-natal sex determination ads. Supreme Court directs the Union of India to constitute a “Nodal Agency” and give due advertisement in television, newspapers and …

Minimally symptomatic infection in an Ebola ‘hotspot’: A cross-sectional serosurvey

Evidence for minimally symptomatic Ebola virus (EBOV) infection is limited. During the 2013–16 outbreak in West Africa, it was not considered epidemiologically relevant to published models or projections of intervention effects. In order to improve our understanding of the transmission dynamics of EBOV in humans, we investigated the occurrence of …

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