Order of the Supreme Court of India in the matter of Network of People Living With HIV/AIDS & Others Vs Union of India & Others dated 24/02/2025. The Supreme Court (SC), February 24, 2025 has directed all states to file their affidavits addressing concerns raised about antiretroviral therapy (ART) drugs …
New Delhi: Although Delhi has witnessed a lot of relief from the monsoon rains, it has come with a price – a spurt in mosquito breeding. This spike in mosquito breeding has unfortunately paved the way for the spread of diseases like chikungunya. As per the Times of India (TOI), …
Despite evidence of substantial comorbidity between psychiatric disorders and substance involvement, the extent to which common genetic factors contribute to their co-occurrence remains understudied. In the current study, we tested for associations between polygenic risk for psychiatric disorders and substance involvement (i.e., ranging from ever-use to severe dependence) among 2573 …
The world is in the grip of a global crisis that kills the equivalent of the populations of Philadelphia, Kampala or Prague - around 1.6 million each year. A new report by a University of Manchester academic, published today in the Journal of Antimicrobial Chemotherapy, documents how many countries do …
One drug can treat three deadly and neglected infections - Chagas disease, leishmaniasis and sleeping sickness - animal studies show. It has been described as a "new hope" for tackling the parasitic infections which affect millions of people in the poorest parts of the world. The discovery, reported in the …
Scientists say they are a step closer to providing effective treatments for three "neglected" diseases after making a chemical which can kill the parasites that cause the illnesses. Chagas disease, leishmaniasis and human African trypanosomiasis (also known as sleeping sickness) affect 20 million people worldwide and lead to more than …
Chagas disease, leishmaniasis and sleeping sickness affect 20 million people worldwide and lead to more than 50,000 deaths annually. The diseases are caused by infection with the kinetoplastid parasites Trypanosoma cruzi, Leishmania spp. and Trypanosoma brucei spp., respectively. These parasites have similar biology and genomic sequence, suggesting that all three …
The vast majority of systemic bacterial infections are caused by facultative, often antibiotic-resistant, pathogens colonizing human body surfaces. Nasal carriage of Staphylococcus aureus predisposes to invasive infection, but the mechanisms that permit or interfere with pathogen colonization are largely unknown. Whereas soil microbes are known to compete by production of …
NEW DELHI: Health may soon be declared a fundamental right of every individual, similar to education, if the draft National Health Policy proposed by the ministry goes through. Pending for nearly two years, the draft is expected to be sent to the Cabinet early next month, official sources said. "We …
WHO recommends combinations of an artemisinin derivative plus an antimalarial drug of longer half-life as treatment options for uncomplicated Plasmodium falciparum infection. In Africa, artemether–lumefantrine is the most widely used artemisinin-based combination therapy, whereas artesunate–mefl oquine is used infrequently because of a perceived poor tolerance to mefl oquine. WHO recommends …
The country has developed the biggest programme of antiretroviral therapy in the world. Now scientists are exploring the long-term consequences of the drugs. Original Source
HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these cells may lead to novel therapeutic strategies to reduce the size of the HIV reservoir. We hypothesized that CD4+ T cells expressing immune checkpoint molecules would be …
A large number of diseases have been grouped together as ‘rare diseases’, because we do not know much about them. There is no consensus on the definition of a rare disease. This is because, obtaining reliable statistical estimates of the frequency of occurrence of a rare event, such as prevalence …
Engineers at the Massachusetts Institute of Technology (MIT) have developed a new type of customizable vaccine that could work against Ebola and other disease outbreaks, and could be deployed faster than traditional vaccines. The vaccine can be manufactured in one week, which allows for rapid deployment to areas affected by …
In a major breakthrough, researchers of the Indian Institute of Science (IISc), Bengaluru, have identified a protein - Rv1860 - which can stimulate protective immunity against tuberculosis (TB). According to the research team, immune responses to this protein are distinctly different in healthy people when compared to TB patients. This …
Two Zika vaccine candidates have shown promising results in pre-clinical trials, scientists have announced. A single shot of either vaccines appeared effective in protecting mice from an infection, in the weeks that followed immunisation. On 1 February 2016, the World Health Organisation declared Zika a public health emergency of international …
A single dose of an experimental vaccine can protect mice against the Zika virus, raising renewed hope of a vaccine for humans, say scientists. The US team say the results, published in Nature, are "striking" and should "galvanise" research efforts. Tests in humans could begin in months. But even if …
About 5.7 million Americans have heart failure, half of whom will die from the disease within 5 years, according to the Centers for Disease Control and Prevention (CDC). Two processes help drive the disease: a weakened heart muscle that is less able to pump, and the death of heart cells …
Right now, people often associate the use of drones with warfare. But in the future they could serve humanitarian purposes, such as delivering aid to people in developing countries. For example, the pilotless flying machines might offer a cheaper and better way to deliver vaccines. And that could potentially boost …
When he realized he was not going to make it as a guitarist, Hiroaki Suga set out to find the origin of life, and ended up creating a new way to develop medicines. Many years spent fiddling with the building blocks of the universe — combining molecules to form compounds …
Scientists have identified a single gene pathway that can disrupt Zika and similar viruses from spreading in the body and also act as a potential drug target for such deadly diseases. The findings showed that disabling SPCS1 -- in both human and insect cells -- reduces viral infection and does …
