Drugs
Order of the Supreme Court regarding ART drugs for people living with HIV/AIDS, 24/02/2025
Order of the Supreme Court of India in the matter of Network of People Living With HIV/AIDS & Others Vs Union of India & Others dated 24/02/2025. The Supreme Court (SC), February 24, 2025 has directed all states to file their affidavits addressing concerns raised about antiretroviral therapy (ART) drugs …Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt
This study addresses the evolutionary dynamics of antimalarial drug resistance after changes in drug use. We show that chloroquine resistance in Plasmodium falciparum from French Guiana was lost after sustained drug removal, whereas the resistance marker PfCRT K76T remained fixed in the parasite population. This phenotypic reversion was caused by …Can we model a cognitive footprint of interventions and policies to help to meet the global challenge of dementia?
he changing global demographic characteristics of dementia have led to worldwide predictions of unaffordable treatment and care costs over the coming decades. Recognition of the economic consequences has encouraged many countries to develop national dementia plans, as well as international actions such as the G8 Dementia Summit in London, UK, …Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial
The RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated with the prevention of Plasmodium falciparum infection. We assessed the association between anti-circumsporozoite antibody titres and the magnitude and duration of vaccine efficacy using data from a phase 3 trial done between 2009 and 2014. Using data from 8922 …Ferroquine and artesunate in African adults and children with Plasmodium falciparum malaria: a phase 2, multicentre, randomised, double-blind, dose-ranging, non-inferiority study
Artemisinin-based combination therapies (ACTs) are the recommended first-line treatment for uncomplicated Plasmodium falciparum malaria. Ferroquine is a new combination partner for fast-acting ACTs such as artesunate. We aimed to assess different doses of ferroquine in combination with artesunate against uncomplicated P falciparum malaria in a heterogeneous population in Africa.Development of high-yield influenza A virus vaccine viruses
Vaccination is one of the most cost-effective ways to prevent infection. Influenza vaccines propagated in cultured cells are approved for use in humans, but their yields are often suboptimal. Here, we screened A/Puerto Rico/8/34 (PR8) virus mutant libraries to develop vaccine backbones (defined here as the six viral RNA segments …Ban on diclofenac, a lifeline for vultures
KOZHIKODE: The Union government decision to ban multi-dose vials of painkiller drug diclofenac has sparked fresh hopes for the survival of three critically-endangered vulture species in the state, the combined population of which is currently below 50 inside the Wayanad Wildlife Sanctuary (WWS). Their breeding population at last count was …The contribution of cervicovaginal infections to the immunomodulatory effects of hormonal contraception
Particular types of hormonal contraceptives (HCs) and genital tract infections have been independently associated with risk of HIV-1 acquisition. We examined whether immunity in women using injectable depot medroxyprogesterone acetate (DMPA), combined oral contraceptives (COC), or no HCs differs by the presence of cervicovaginal infections. Immune mediators were quantified in …DGCI to soon regulate metals in cosmetics
The Drug Controller General of India (DCGI) has started to regulate cosmetics laced with heavy metals after the Drug Technical advisory Board (DTAB), country’s apex body on drugs, proposed to restrict the presence of mercury in cosmetics. The use of mercury was earlier prohibited in cosmetics. In the amendments proposed …Necitumumab in metastatic squamous cell lung cancer - Establishing a value-based cost
The SQUIRE trial demonstrated that adding necitumumab to chemotherapy for patients with metastatic squamous cell lung cancer (mSqCLC) increased median overall survival by 1.6 months (hazard ratio, 0.84). However, the costs and value associated with this intervention remains unclear. Value-based pricing links the price of a drug to the benefit …Effectiveness of provider and community interventions to improve treatment of uncomplicated malaria in Nigeria: A cluster randomized controlled trial
The World Health Organization recommends that malaria be confirmed by parasitological diagnosis before treatment using Artemisinin-based Combination Therapy (ACT). Despite this, many health workers in malaria endemic countries continue to diagnose malaria based on symptoms alone. This study evaluates interventions to help bridge this gap between guidelines and provider practice. …The impact of a one-dose versus two-dose oral cholera vaccine regimen in outbreak settings: A modeling study
In 2013, a stockpile of oral cholera vaccine (OCV) was created for use in outbreak response, but vaccine availability remains severely limited. Innovative strategies are needed to maximize the health impact and minimize the logistical barriers to using available vaccine. Here we ask under what conditions the use of one …No answer yet to antibiotic abuse
KOLKATA: Thanks to indiscriminate use of antibiotics, infection control may become a tough task in the city. In another couple of years, doctors may have no answer to diseases like pneumonia, urinary tract infection, skin infection and blood septicemia. The emergence of new bacteria and fungi, too, are making treatment …Tackle Nepal’s typhoid problem now
The news that a promising vaccine has been tested against Ebola is very welcome. But, as we in Nepal know only too well, the development of a vaccine is no guarantee that it will be used. Back in 1987, a successful trial of a typhoid vaccine here in Kathmandu gave …Brazil to release its own dengue vaccine by 2018
Brazil announced on Thursday that the vaccination against dengue developed by the country will be available by 2018 when all the tests are finished. "We are currently hoping for a safe vaccine against dengue to be developed fully ... At best we will have the vaccine in 2018," said Brazil's …Cuba develops vaccine for chronic hepatitis B
HAVANA, Cuba (CMC) — The new Cuban vaccine for the treatment of chronic hepatitis B is currently undergoing clinical trials in Cuba and eight Asian countries, with the cooperation of the French company Abivax. Researchers say the new product -- HeberNasvac -- developed by researchers of the Centre for Genetic …Dengue alert: No aspirin over the counter
The Delhi government on Tuesday banned sale of non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, disprin, brufen and voveran without a prescription because of the danger these drugs pose to dengue patients. A senior official said drugs such as aspirin and ibuprofen cause destruction of blood platelets.“These drugs may aggravate …Order of the Delhi High Court regarding patent for a pharmaceutical product titled “Carboxyarly Substituted Diphenyl Ureas”, 12/08/2015
Order of the Delhi High Court in the matter of Bayer Corporation Vs Union of India & Others dated 12/08/2015 regarding patent for a pharmaceutical product titled “Carboxyarly Substituted Diphenyl Ureas”.The Vancouver Consensus: antiretroviral medicines, medical evidence, and political will
In 1996, the global HIV community gathered in Vancouver, Canada, for the XI International AIDS Conference and shared the clear evidence that triplecombination antiretroviral treatment held the power to stem the tide of deaths from AIDS. The HIV treatment era had begun. As we gathered again in Vancouver in July, …Use of combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases
The objective of the study was to investigate the association between use of combined oral contraceptives and risk of venous thromboembolism, taking the type of progestogen into account. Original SourceHow Ebola-vaccine success could reshape clinical-trial policy
When Ebola broke out in West Africa in December 2013, triggering the largest-ever epidemic of the disease, there was no vaccine or drug that had been shown to be safe and effective in people. Just 20 months later, a vaccine seems to confer total protection against infection, according to the …