Toxicity Studies

State of the Climate in Asia 2024

The World Meteorological Organization’s State of the Climate in Asia 2024 report warns that the region is warming nearly twice as fast as the global average, driving more extreme weather and posing serious threats to lives, ecosystems, and economies. In 2024, Asia experienced its warmest or second warmest year on …

Laboratory rodent diets contain toxic levels of environmental contaminants: Implications for regulatory tests

The quality of diets in rodent feeding trials is crucial. We describe the contamination with environmental pollutants of 13 laboratory rodent diets from 5 continents. Measurements were performed using accredited methodologies. All diets were contaminated with pesticides (1-6 out of 262 measured), heavy metals (2-3 out of 4, mostly lead …

Reproductive toxicity of a mixture of regulated drinking-water disinfection by-products in a multigenerational rat bioassay

Trihalomethanes (THMs) and haloacetic acids (HAAs) are regulated disinfection by-products (DBPs); their joint reproductive toxicity in drinking water is unknown. The researchers aimed to evaluate a drinking water mixture of the four regulated THMs and five regulated HAAs in a multigenerational reproductive toxicity bioassay.

Reproductive toxicity of a mixture of regulated drinking-water disinfection by-products in a multigenerational rat bioassay

Trihalomethanes (THMs) and haloacetic acids (HAAs) are regulated disinfection by-products (DBPs); their joint reproductive toxicity in drinking water is unknown. The researchers aimed to evaluate a drinking water mixture of the four regulated THMs and five regulated HAAs in a multigenerational reproductive toxicity bioassay.

Transgenerational effects from early developmental exposures to bisphenol A or 17α-ethinylestradiol in medaka, Oryzias latipes

The transgenerational consequences of environmental contaminant exposures of aquatic vertebrates have the potential for broad ecological impacts, yet are largely uninvestigated. Bisphenol A (BPA) and 17α-ethinylestradiol (EE2) are two ubiquitous estrogenic chemicals present in aquatic environments throughout the United States and many other countries. Original Source

Impact of the pesticide endosulfan 35% ec on the haematological parameters of fresh water fish, cirrhinus mrigala

Pesticidal stress is very common factor today in human health and animal health. Most of the world s population depends upon fish food. Fishes can serve as bioindicators of environmental pollution since they are directly exposed to chemicals resulting from agricultural production via surface run off or in directly through …

Marine invertebrates as bioindicators of heavy metal pollution

Atmosphere, earth and water compose the environment. The presence of heavy metals in the environment has grown because of their large employment in some industrial and agricultural activities. Although these metals are terrestrial products, they flow into the sea through effluents and sewage or are directly discharged from industries placed …

Prenatal phthalate exposures and anogenital distance in Swedish boys

Phthalates are used as plasticizers in soft polyvinyl chloride (PVC) and in a large number of consumer products. Due to reported health risks, di-isononyl phthalate (DiNP) has been introduced as a replacement for diethyl hexyl phthalate (DEHP) in soft PVC. This raises concerns since animal data suggest that DiNP may …

Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential

Mitochondrial dysfunction has been implicated in the pathogenesis of a variety of disorders including cancer, diabetes, and neurodegenerative and cardiovascular diseases. Understanding whether different environmental chemicals and drug-like molecules impact mitochondrial function represents an initial step in predicting exposure-related toxicity and defining a possible role for such compounds in the …

Aerial application of Mancozeb and Urinary Ethylene Thiourea (ETU) concentrations among pregnant women in Costa Rica: The Infants’ Environmental Health Study (ISA)

Mancozeb and its main metabolite ethylene thiourea (ETU) may alter thyroid function; thyroid hormones are essential for fetal brain development. In Costa Rica, mancozeb is aerially sprayed at large-scale banana plantations on a weekly basis. The objectives of the study was to (1) evaluate urinary ETU concentrations in pregnant women …

Water in 31 districts polluted with arsenic

The groundwater in nearly 31 districts in Uttar Pradesh has been found to have a strong arsenic contamination which exposes the people to slow and consistent toxin. A technical report titled Arsenic toxicity in ground water of Uttar Pradesh shows that the concentration of arsenic in groundwater exceeds the Bureau …

Carcinogenicity of perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone

In June, 2014, 20 experts from nine countries met at the International Agency for Research on Cancer (IARC; Lyon, France) to assess the carcinogenicity of perfluorooctanoic acid (PFOA), tetrafluoroethylene (TFE), dichloromethane (DCM), 1,2-dichloropropane (1,2-DCP), and 1,3-propane sultone (1,3-PS). These assessments will be published as volume 110 of the IARC Monographs.

Environmental safety of the use of major surfactant classes in North America

This paper brings together over 250 published and unpublished studies on the environmental properties, fate, and toxicity of the four major, high-volume surfactant classes and relevant feedstocks. The surfactants and feedstocks covered include alcohol sulfate or alcohol sulfate (AS), alcohol ethoxysulfate (AES), linear alkylbenzene sulfonate (LAS), alcohol ethoxylate (AE), and …

Children & pesticides: protect our children from toxic pesticides

Children today are sicker than they were a generation ago. The past few decades have seen a rapid rise in the consumption of synthetic pesticides. The world now uses about 2.3 million tonnes of pesticides every year, which is 50 times more than in 1950. The widespread use of pesticides …

A little story about a fashionable lie

A new investigation by Greenpeace International has found a broad range of hazardous chemicals in children's clothing and footwear produced by eight luxury fashion brands. Twenty-seven products were sent to independent accredited laboratories, and investigated for the presence of nonylphenol ethoxylates (NPEs), and certain products were also analysed for phthalates, …

Hazardous chemicals in branded luxury textile products on sale during 2013

Greenpeace has recently published a number of investigations showing that a wide range of textile products, manufactured and sold in many countries around the world, can contain residues of hazardous substances, including hormone-disrupting alkylphenols and their ethoxylates, reprotoxic phthalates, highly persistent per- and polyfluorinated chemicals, and – in some cases …

Acute toxicity of Synthetic Pyrethroid Cypermethrin on protein content in estuarine clam, Marcia Opima (Gmelin, 1791)

Cypermethrin is a synthetic pyrethoid mainly used against mango insect pests. Clams are good indicators of pesticide pollution and are known to be tolerant to pesticide accumulation. Acute toxicity experiment of Cypermethrin is carried out on estuarine clam, Marcia opima. The clam exhibited significant increase in protein content of gill …

Leaching of bisphenol A from baby bottles

Dietary exposure of children to Bisphenol A through feeding bottles under real use conditions was investigated. Polycarbonate is widely used in the manufacture of food containers and Bisphenol A can leach out into liquid food material. Three sets of six feeding bottles each from different brands were used in the …

Toxicity of deepwater horizon source oil and the chemical dispersant, corexit® 9500, to coral larvae

Acute catastrophic events can cause significant damage to marine environments in a short time period and may have devastating long-term impacts. In April 2010 the BP-operated Deepwater Horizon (DWH) offshore oil rig exploded, releasing an estimated 760 million liters of crude oil into the Gulf of Mexico. This study examines …

Combined pesticide exposure severely affects individual- and colony-level traits in bees

Chronic exposure of bumblebees to two pesticides (a neonicotinoid and a pyrethroid) independently and in combination, at concentrations approximating field-level exposure, impairs natural foraging behaviour and increases worker mortality, with knock-on effects for brood development and colony success.

India’s Minamata

Mercury, a highly toxic heavy metal, has contaminated the environment of Sonbhadra in Uttar Pradesh. This new lab study by Centre for Science and Environment found the metal in not just soil and water samples, but also in people's blood. Singrauli, the powerhouse of India with massive coal reserves and …

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