Toxicity Studies

State of the Climate in Asia 2024

The World Meteorological Organization’s State of the Climate in Asia 2024 report warns that the region is warming nearly twice as fast as the global average, driving more extreme weather and posing serious threats to lives, ecosystems, and economies. In 2024, Asia experienced its warmest or second warmest year on …

Bottles can be toxic - Part II

In spite of the prohibition on the use of Bisphenol-A (BPA) in baby feeding bottles, the toxic chemical continues to be found in some baby products sold in the Indian market. BPA is an endocrine disrupting chemical that has been accepted as the chemical of concern globally. It is a …

Order of the Supreme Court of India regarding provision of clean drinking water to residents living around Union Carbide plant, Bhopal, Madhya Pradesh, 18/04/2018

Order of the Supreme Court of India in the matter of Research Foundation for Science Vs Union of India & Others dated 18/04/2018 regarding provision of clean drinking water to residents living around Union Carbide plant, Bhopal, Madhya Pradesh. In the response filed on behalf of the State of Madhya …

Airborne polycyclic aromatic compounds contribute to the induction of the tumour-suppressing P53 pathway in wild double-crested cormorants

Polycyclic aromatic compounds (PACs), including polycyclic aromatic hydrocarbons (PAHs) and PAH-like compounds are known or probable environmental carcinogens released into the environment as a by-product of incomplete combustion of fossil fuels and other organic materials. Studies have shown that exposure to PACs in the environment can induce both genotoxicity and …

Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC

Glyphosate is the most widely used herbicide worldwide. It is a broad spectrum herbicide and its agricultural uses increased considerably after the development of glyphosate-resistant genetically modified (GM) varieties. Since glyphosate was introduced in 1974, all regulatory assessments have established that glyphosate has low hazard potential to mammals, however, the …

The enigma of litchi toxicity: an emerging health concern in southern Asia

How is it possible that lychee, a deliciously sweet tropical fruit, could induce a fatal hypoglycemic encephalopathy in children? The answer is straightforward: the edible fruit (aril) of lychee or litchi (Litchi sinensis or Litchi chinensis), and other members of the Soapberry family (Sapindaceae), contains unusual amino acids that disrupt …

Extended chronology of the Cordón Caulle volcanic eruption beyond 2011 reveals toxic impacts

Aside of immediate impacts, the 2011 Puyehue–Cordón Caulle volcano (PCC) eruption also caused persisting chemical impacts. By 2012, toxicity resulted in overt dental fluorosis in deer, with bone fluoride increasing > 38-fold to 5175 ppm. Sheep, horses and cattle also succumbed to fluorosis. Due to eolian redeposition of tephra, exposure …

Formaldehyde is a potent proteotoxic stressor causing rapid heat shock transcription factor 1 activation and Lys48-linked polyubiquitination of proteins

Endogenous and exogenous formaldehyde (FA) has been linked to cancer, neurotoxicity, and other pathophysiologic effects. Molecular and cellular mechanisms that underlie FA-induced damage are poorly understood. In this study, we investigated whether proteotoxicity is an important, unrecognized factor in cell injury caused by FA. Original Source

Glyphosate Issue Paper: Evaluation of carcinogenic potential

Glyphosate is a non-selective, phosphonomethyl amino acid herbicide registered to control weeds in various agricultural and non-agricultural settings. The herbicide acts by inhibiting the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) enzyme, which is not present in mammalian systems. Glyphosate was initially registered in 1974. Since then, several human health analyses have been completed …

Assessment of food and environmental safety (AFES) for environmental release of genetically engineered mustard hybird DMH-11 and use of parental events for development of new …

Assessment of food and environmental safety (AFES) for environmental release of genetically engineered mustard hybird DMH-11 and use of parental events for development of new generation hybirds

Perinatal DDT exposure induces hypertension and cardiac hypertrophy in adult mice

Dichlorodiphenyltrichloroethane (DDT) was used extensively to control malaria, typhus, body lice, and bubonic plague worldwide, until countries began restricting its use in the 1970s. However, use of DDT to control vector-borne diseases continues in developing countries. Prenatal DDT exposure is associated with elevated blood pressure in humans. Original Source

Course to analyse chemicals

Mysuru: Sri Jayachamarajendra College of Engineering (SJCE) under its third Global Initiative of Academic Networks (GIAN) programme will organize a 10-day course on 'fate and transport of contaminants in the environment' on its premises from Monday. The course tutor is professor Rajesh Seth, department of civil and environmental engineering, University …

Prioritizing environmental chemicals for obesity and diabetes outcomes research: A screening approach using ToxCast high throughput data

Diabetes and obesity are major threats to public health in the US and abroad. Understanding the role chemicals in our environment play in the development of these conditions is an emerging issue in environmental health, although identifying and prioritizing chemicals for testing beyond those already implicated in the literature is …

Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA)

The International Agency for Research on Cancer (IARC) Monographs Programme identifies chemicals, drugs, mixtures, occupational exposures, lifestyles and personal habits, and physical and biological agents that cause cancer in humans and has evaluated about 1000 agents since 1971. Monographs are written by ad hoc Working Groups (WGs) of international scientific …

Seasonal study of acute toxicity of tributyltin oxide (TBTO) on the fresh water bivalve, Lamellidens marginalis from Godavari river at Maharashtra, India

The aim of the present study is to investigate LC50 values in three seasons of TBTO on L. marginalis. The active substance TBT is highly toxic damaging to non target species. The bivalves have been bioindicators to determine aquatic pollution status. The adverse effect of Tributyltin oxide has been studied …

Multi-residue method for the determination of pesticides and pesticide metabolites in honeybees by liquid and gas chromatography coupled with tandem mass spectrometry—Honeybee poisoning incidents

A method for the determination of 200 pesticides and pesticide metabolites in honeybee samples has been developed and validated. Almost 98% of compounds included in this method are approved to use within European Union, as active substances of plant protection products or veterinary medicinal products used by beekeepers to control …

Reconciling laboratory and field assessments of neonicotinoid toxicity to honeybees

European governments have banned the use of three common neonicotinoid pesticides due to insufficiently identified risks to bees. This policy decision is controversial given the absence of clear consistency between toxicity assessments of those substances in the laboratory and in the field. Although laboratory trials report deleterious effects in honeybees …

Phthalate in children’s toys and childcare articles in Croatia

Children’s toys are made of artificial material often softened by phthalates. These are synthetic compounds added to PVC as plasticizers for the purpose of improving its elasticity and flexibility. Phthalates can endanger the health of children exposed to their effect by inducing reproductive, hormonal and developmental disorders. The goal of …

Toxicity study in mice fed with corn produced in soil containing tannery sludge vermicompost and irrigated with domestic wastewater

Growing food in unconventional systems such as those using irrigation with domestic wastewater and the use of potentially toxic waste has generated resistance from producers and consumers. Here, we evaluate the possible physical and biochemical damage to Swiss mice fed for 13 weeks with corn produced in soil containing tannery …

Histopathological alterationsin muscle, liver and gill tissues of zebra fish Danio Rerio due to environmentally relevant concentrations of organochlorine pesticides (OCPs) and heavy metals

The study monitored the toxicity of environmentally relevant concentration of pesticides and metals in zebra fish Danio rerio. Zebra fish were exposed to environmentally relevant concentration of pesticides and metals for a period of 14 days. The individual and the combined toxicity of pesticides and metals were evaluated. The pesticides …

Organophosphate insecticide metabolites in prenatal and childhood urine samples and intelligence scores at 6 years of age: Results from the Mother-Child PELAGIE Cohort (France)

Several studies suggest that exposure to organophosphate insecticides (OP) during pregnancy impairs neurodevelopment in children. The researchers evaluated associations between biomarkers of prenatal and postnatal OP exposure and cognitive function of 6-year-olds in a French longitudinal birth cohort. Original Source

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