Research

R&D roadmap for green hydrogen ecosystem in India

The Ministry of New and Renewable Energy has published the R&D; Roadmap for Green Hydrogen Ecosystem in India. This document was published on 13th October, 2023. One of the central pillars of the National Green Hydrogen Mission is the establishment of a supportive research and innovation ecosystem for green hydrogen …

Self-organization of the human embryo in the absence of maternal tissues

Remodelling of the human embryo at implantation is indispensable for successful pregnancy. Yet it has remained mysterious because of the experimental hurdles that beset the study of this developmental phase. Here, we establish an in vitro system to culture human embryos through implantation stages in the absence of maternal tissues …

Security spending must cover disease outbreaks

The health emergency precipitated by the Zika virus is a salutary reminder: global preparedness for emerging pathogens with endemic or pandemic potential is crucial and needs an overhaul. These crises are not rare — Lassa fever, Ebola virus, Middle East respiratory syndrome, H1N1 influenza and severe acute respiratory syndrome (SARS) …

Maternal IgG and IgA antibodies dampen mucosal T helper cell responses in early life

To maintain a symbiotic relationship between the host and its resident intestinal microbiota, appropriate mucosal T cell responses to commensal antigens must be established. Mice acquire both IgG and IgA maternally; the former has primarily been implicated in passive immunity to pathogens while the latter mediates host-commensal mutualism. Here, we …

Between pleasure and contentment: Evolutionary dynamics of some possible parameters of happiness

The survival of the fittest might just be the survival of the steadfast instead. Researchers say having a positive attitude is advantageous in a computational model that simulates evolution. We offer and test a simple operationalization of hedonic and eudaimonic well-being (“happiness”) as mediating variables that link outcomes to motivation. …

Effectiveness of interventions to indirectly support food and drink intake in people with dementia: Eating and Drinking Well IN dementiA (EDWINA) systematic review

Risks and prevalence of malnutrition and dehydration are high in older people but even higher in older people with dementia. In the EDWINA (Eating and Drinking Well IN dementiA) systematic review we aimed to assess effectiveness of interventions aiming to improve, maintain or facilitate food/drink intake indirectly, through food service …

The blunted effect of glucose-dependent insulinotropic polypeptide in subcutaneous abdominal adipose tissue in obese subjects is partly reversed by weight loss

Glucose-dependent insulinotropic polypeptide (GIP) appears to have impaired effect on subcutaneous abdominal adipose tissue metabolism in obese subjects. The aim of the present study was to examine whether weight loss may reverse the impaired effect of GIP on subcutaneous abdominal adipose tissue in obese subjects. Original Source

Pomace in fruit industry and their contemporary potential application

Food economy plays a major role in world development. A food chain, from an economic point of view, means a long series of interdependent management processes, which have the main goal to providing food to people. It consists of many elements like food production, harvesting, processing, storage, and trade. Fruit …

Scaling-up treatment of depression and anxiety: a global return on investment analysis

Depression and anxiety disorders are highly prevalent and disabling disorders, which result not only in an enormous amount of human misery and lost health, but also lost economic output. Here we propose a global investment case for a scaled-up response to the public health and economic burden of depression and …

Cigarette smoke but not electronic cigarette aerosol activates a stress response in human coronary artery endothelial cells in culture

It is generally acknowledged that e-cigarettes are unlikely to be as harmful as conventional cigarettes, but there is little data that quantifies their relative harms. We investigated the biological response to e-cigarette aerosol exposure (versus conventional cigarette smoke exposure) at the cellular level, by exposing human coronary artery endothelial cells …

Effects of stone crusher dust pollution on growth performance and yield status of rice (Oryza sativa. L)

In the present investigation the effect of stone crushing dust pollution on the growth performance and yield status of Rice (Oryza sativa) was studied in specified land areas of village Arap, Patna. The results indicated that the germination frequency of seeds, shoot length, root length, chlorophyll content, total carbohydrate and …

Cold chain and virus-free chloroplast-made booster vaccine to confer immunity against different poliovirus serotypes

The WHO recommends complete withdrawal of oral polio vaccine (OPV) type 2 by April 2016 globally and replacing with at least one dose of inactivated poliovirus vaccine (IPV). However, high-cost, limited supply of IPV, persistent circulating vaccine-derived polioviruses transmission and need for subsequent boosters remain unresolved. To meet this critical …

CSIRO sets up special climate centre but doubts remain over scale of cuts

The CSIRO will split its climate science into two, creating a special unit based in Hobart but leaving in doubt the future of at least 50 climate researchers. A new CSIRO Climate Science Centre, foreshadowed by Fairfax Media, will coordinate the work of 40 scientists carved out of existing CSIRO …

Eating for trillions

Three studies investigate the bacteria in the guts of malnourished children and find that, when this microbiota is transferred into mice, supplements of certain microbes or sugars from human breast milk can restore normal growth.

Zika virus impairs growth in human neurospheres and brain organoids

Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased significantly in Brazil; however, causality between the viral epidemic and malformations in fetal brains needs further confirmation. Here, we examine the effects of ZIKV infection in human neural stem cells growing as neurospheres and brain organoids. Using immunocytochemistry …

A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis

Wogonin and baicalein are bioactive flavones in the popular Chinese herbal remedy Huang-Qin (Scutellaria baicalensis Georgi). These specialized flavones lack a 4′-hydroxyl group on the B ring (4′-deoxyflavones) and induce apoptosis in a wide spectrum of human tumor cells in vitro and inhibit tumor growth in vivo in different mouse …

A genetic-based algorithm for personalized resistance training

Association studies have identifed dozens of genetic variants linked to training responses and sport-related traits. However, no intervention studies utilizing the idea of personalised training based on athlete’s genetic profle have been conducted. Here we propose an algorithm that allows achieving greater results in response to high- or low-intensity resistance …

Resistance of feather-associated bacteria to intermediate levels of ionizing radiation near Chernobyl

Ionizing radiation has been shown to produce negative effects on organisms, although little is known about its ecological and evolutionary effects. As a study model, we isolated bacteria associated with feathers from barn swallows Hirundo rustica from three study areas around Chernobyl differing in background ionizing radiation levels and one …

Acute stimulation of mesenchymal stem cells with cigarette smoke extract affects their migration, differentiation, and paracrine potential

Mesenchymal stem cells (MSCs) are known to play a key role in tissue regeneration, while smoking cigarettes is described to impair it. This work focuses on the effect cigarette smoke extract (CSE) has on the migration, differentiation, and paracrine potential of human adipose derived MSCs (AdMSCs). To mimic native conditions …

What fossils reveal about the protozoa progenitors, geographic provinces, and early hosts of malarial organisms

In 1991, Robert S. Desowitz asked, “Did the primitive malaria begin as a parasite of some prehistoric reptile that later was picked up by a mosquito, or was it first a parasite of the mosquito that later became established in the reptile?” This question has been debated for years and …

Integrating gender into climate change adaptation programs: a research and capacity needs assessment for Sub-Saharan Africa

Research shows that paying attention to gender matters not only for the equity of climate change adaptation programs but also for their efficiency and effectiveness. Many organizations working to increase resilience to climate change with local communities also recognize the importance of gender yet the degree to which gender is …

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