Research

R&D roadmap for green hydrogen ecosystem in India

The Ministry of New and Renewable Energy has published the R&D; Roadmap for Green Hydrogen Ecosystem in India. This document was published on 13th October, 2023. One of the central pillars of the National Green Hydrogen Mission is the establishment of a supportive research and innovation ecosystem for green hydrogen …

Common oncogene mutations and novel SND1-BRAF transcript fusion in lung adenocarcinoma from never smokers

Lung adenocarcinomas from never smokers account for approximately 15 to 20% of all lung cancers and these tumors often carry genetic alterations that are responsive to targeted therapy. Here we examined mutation status in 10 oncogenes among 89 lung adenocarcinomas from never smokers. We also screened for oncogene fusion transcripts …

Silica triggers inflammation and ectopic lymphoid neogenesis in the lungs in parallel with accelerated onset of systemic autoimmunity and glomerulonephritis in the lupus-prone NZBWF1 mouse

Genetic predisposition and environmental factors influence the development of human autoimmune disease. Occupational exposure to crystalline silica (cSiO2) has been etiologically linked to increased incidence of autoimmunity, including systemic lupus erythematosus (SLE), but the underlying mechanisms are poorly understood. The purpose of this study was to test the hypothesis that …

Fat/carbohydrate ratio but not energy density determines snack food intake and activates brain reward areas

The snack food potato chips induces food intake in ad libitum fed rats, which is associated with modulation of the brain reward system and other circuits. Here, we show that food intake in satiated rats is triggered by an optimal fat/carbohydrate ratio. Like potato chips, an isocaloric fat/carbohydrate mixture influenced …

A nation with ambition

India is making great strides in improving its science, but it needs to look carefully at its approach and work with the rest of the world if it is to realize its full potential. (Editorial) Original Source

India's science test

Despite great strides in some areas of research and development, the nation still has a long way to go. Original Source

Priorities for science in India

Ten Indian research leaders give their prescriptions, from better funding, facilities, mentoring and education to greater respect, fairness, autonomy and confidence. Sunita Narain: Manage waste frugally Hiriyakkanavar Ila: Support the bulk of students Yamuna Krishnan: Crack the cliques, enable visionaries Joyashree Roy: Train more energy economists Raghavendra Gadagkar: Solve local …

Geothermal systems in the Northwest Himalaya

Conventional energy resources are fast depleting and therefore alternative resources are required to sustain the fast progress and development of any nation. This situation is more pertinent to India where fast growing population and developmental activities are posing major challenges to the government as the country has limited resources of …

Efficacy of yoga for depressed postpartum women: A randomized controlled trial

Up to 20% of women experience postpartum depression (PPD). PPD is associated with anxiety and poor health-related quality of life (HRQOL). Efficacious treatments are critical; many women with PPD prefer complementary therapies. Thus, the current study examined yoga as a complementary therapy for PPD. Original Source

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious knowledge gap remains in …

Effects of 1-year yoga on cardiovascular risk factors in middle-aged and older adults with metabolic syndrome: a randomized trial

Metabolic syndrome (MetS) is a clustering of cardiovascular risk factors, which is associated with diabetes mellitus and cardiovascular disease. Lifestyle interventions applied to people with MetS has considerable beneficial effects on disease preventive outcomes. This study aimed to examine the effects of 1-year of yoga exercise on the cardiovascular risk …

Compliance with hospital accreditation and patient mortality: a Danish nationwide population-based study

The objecive of the study was to examine the association between compliance with hospital accreditation and 30-day mortality.

The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial

In adults with acute stroke, infections occur commonly and are associated with an unfavourable functional outcome. In the Preventive Antibiotics in Stroke Study (PASS) we aimed to establish whether or not preventive antimicrobial therapy with a third-generation cephalosporin, ceftriaxone, improves functional outcome in patients with acute stroke.

Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, …

Ebola virus and Marburg virus cause serious disease outbreaks with high case fatality rates. We aimed to assess the safety and immunogenicity of two investigational DNA vaccines, one (EBO vaccine) encoding Ebola virus Zaire and Sudan glycoproteins and one (MAR) encoding Marburg virus glycoprotein.

Assessment of chronic sublethal effects of Imidacloprid on honey bee colony health

The researchers present results of a three-year study to determine the fate of imidacloprid residues in hive matrices and to assess chronic sublethal effects on whole honey bee colonies fed supplemental pollen diet containing imidacloprid at 5, 20 and 100 μg/kg over multiple brood cycles. Various endpoints of colony performance …

Electric light, particularly at night, disrupts human circadian rhythmicity: is that a problem?

Over the past 3 billion years, an endogenous circadian rhythmicity has developed in almost all life forms in which daily oscillations in physiology occur. This allows for anticipation of sunrise and sunset. This physiological rhythmicity is kept at precisely 24 h by the daily cycle of sunlight and dark. However, …

Black Carbon & India's climate what is known and need for further research

Presentation by A. Jayaraman, Director, National Atmospheric Research Laboratory, Department of Space, Government of India at the Anil Agarwal Dialogue 2015: Poor in climate change, India Habitat Centre, New Delhi, March 11 – 12, 2015

Sugar industry influence on the scientific agenda of the National Institute of Dental Research’s 1971 National Caries Program: A historical analysis of internal documents

In 1966, the National Institute of Dental Research (NIDR) began planning a targeted research program to identify interventions for widespread application to eradicate dental caries (tooth decay) within a decade. In 1971, the NIDR launched the National Caries Program (NCP). The objective of this paper is to explore the sugar …

Household 'green' products pose health hazards: study

The so-called household 'green' products such as air fresheners, cleaning products, laundry supplies and personal care products emit a range of compounds that could harm human health, a new study has warned. A University of Melbourne researcher has found that common consumer products, including those marketed as 'green', 'all-natural', 'non-toxic' …

A probabilistic model for hydrokinetic turbine collision risks: Exploring impacts on fish

A variety of hydrokinetic turbines are currently under development for power generation in rivers, tidal straits and ocean currents. Because some of these turbines are large, with rapidly moving rotor blades, the risk of collision with aquatic animals has been brought to attention. The behavior and fate of animals that …

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

The intestinal tract is inhabited by a large and diverse community of microbes collectively referred to as the gut microbiota. While the gut microbiota provides important benefits to its host, especially in metabolism and immune development, disturbance of the microbiota–host relationship is associated with numerous chronic inflammatory diseases, including inflammatory …

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