Research

R&D roadmap for green hydrogen ecosystem in India

The Ministry of New and Renewable Energy has published the R&D; Roadmap for Green Hydrogen Ecosystem in India. This document was published on 13th October, 2023. One of the central pillars of the National Green Hydrogen Mission is the establishment of a supportive research and innovation ecosystem for green hydrogen …

‘Division of labour’ in response to host oxidative burst drives a fatal Cryptococcus gattii outbreak

Cryptococcus gattii is an emerging intracellular pathogen and the cause of the largest primary outbreak of a life-threatening fungal disease in a healthy population. Outbreak strains share a unique mitochondrial gene expression profile and an increased ability to tubularize their mitochondria within host macrophages. However, the underlying mechanism that causes …

On the quarantine period for Ebola virus

21 days has been regarded as the appropriate quarantine period for holding individuals potentially exposed to Ebola Virus (EV) to reduce risk of contagion. There does not appear to be a systematic discussion of the basis for this period.

Hand book on horticulture statistics 2014

The establishment of a comprehensive horticulture database is crucial for ensuring effective planning to facilitate a systematic development of the horticulture sector in the country. The data also helps in exploiting the huge export potential for the sector. The present “Hand book on Horticulture Statistics” has been divided into seven …

Evaluation of removal efficiency of Cu (II) from aqueous solution by natural leaves

Activated carbon was prepared from Behda (BEAC), Anjan (AAC), Chinch (CAC), and Bakam Neem (BNAC) leaves. The effects of various parameters such as initial metal concentration, particle size, pH and contact time for the adsorption of Cu (II) on BEAC, AAC, CAC and BNAC were investigated. The amount of adsorbent …

Olfactory dysfunction predicts 5-year mortality in older adults

Prediction of mortality has focused on disease and frailty, although antecedent biomarkers may herald broad physiological decline. Olfaction, an ancestral chemical system, is a strong candidate biomarker because it is linked to diverse physiological processes. We sought to determine if olfactory dysfunction is a harbinger of 5-year mortality in the …

Quantity and timing of maternal prenatal smoking on neonatal body composition: The Healthy Start Study

The objective of the study was to examine the dose-dependent and time-specific relationships of prenatal smoking with neonatal body mass, fat mass (FM), fat-free mass (FFM), and FM-to-FFM ratio, as measured by air-displacement plethysmography (PEA POD system).

A decade of development in Sub Saharan African science, technology, engineering and mathematics research

This report analyzes Africa's current performance in Science, Technology, Engineering and Math (STEM) research, as well as future trends. In March 2014 several African governments' ministers agreed on a Joint Call for Action in Kigali to adopt a strategy that uses strategic investments in science and technology to accelerate Africa …

Dry roasting enhances peanut-induced allergic sensitization across mucosal and cutaneous routes in mice

The reasons for the disproportionate contribution of peanuts to prevalent and severe cases of food allergy in the Western world are unclear. Emerging statistics from East Asia generally match the overall common food allergies in the West, with the striking exception of peanuts, which are consumed equivalently in both regions. …

Discovery of a small molecule that inhibits bacterial ribosome biogenesis

While small molecule inhibitors of the bacterial ribosome have been instrumental in understanding protein translation, no such probes exist to study ribosome biogenesis. We screened a diverse chemical collection that included previously approved drugs for compounds that induced cold sensitive growth inhibition in the model bacterium Escherichia coli. Among the …

A spring forward for Hominin evolution in East Africa

Groundwater is essential to modern human survival during drought periods. There is also growing geological evidence of springs associated with stone tools and hominin fossils in the East African Rift System (EARS) during a critical period for hominin evolution (from 1.8 Ma). However it is not known how vulnerable these …

Metagenomic analysis of double-stranded DNA viruses in healthy adults

The Human Microbiome Project (HMP) was undertaken with the goal of defining microbial communities in and on the bodies of healthy individuals using high-throughput, metagenomic sequencing analysis. The viruses present in these microbial communities, the `human virome?, are an important aspect of the human microbiome that is particularly understudied in …

Optical assay of erythrocyte function in banked blood

Stored red blood cells undergo numerous biochemical, structural, and functional changes, commonly referred to as storage lesion. How much these changes impede the ability of erythrocytes to perform their function and, as result, impact clinical outcomes in transfusion patients is unknown. In this study we investigate the effect of the …

Evidence that ebolaviruses and cuevaviruses have been diverging from marburgviruses since the Miocene

An understanding of the timescale of evolution is critical for comparative virologybut remains elusive for many RNA viruses. Age estimates based on mutation rates can severely underestimate divergences for ancient viral genes that are evolving under strong purifying selection. Paleoviral dating, however, can provide minimum age estimates for ancient divergence, …

Comparative study on the effect of energy drinks on haematopoietic system in Wistar albino rats

Energy drinks have become popularized and the market value for these drinks is continually growing. Therefore, the present study aimed to evaluate the effect of three popular kinds of energy drinks (Power Horse, Red Bull and Code Red) on certain hematological parameters and on the ultrastructure of blood cells in …

The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein

Ebolavirus (EBOV) causes severe hemorrhagic fever with a mortality rate of up to 90%. EBOV is a member of the order Mononegavirales and, like other viruses in this taxonomic group, contains a negative-sense single-stranded (ss) RNA. The EBOV ssRNA encodes seven distinct proteins. One of them, the nucleoprotein (NP), is …

International Glossina Genome Initiative 2004–2014: A driver for post-genomic era research on the African continent

Human African trypanosomiasis (HAT), also known as sleeping sickness, is a neglected disease that impacts 70 million people distributed over 1.55 million km2 in sub-Saharan Africa and includes at least 50% of the population of the Democratic Republic of the Congo. Trypanosoma brucei gambiense accounts for more than 98% of …

Cafeteria diet impairs expression of sensory-specific satiety and stimulus-outcome learning

A range of animal and human data demonstrates that excessive consumption of palatable food leads to neuroadaptive responses in brain circuits underlying reward. Unrestrained consumption of palatable food has been shown to increase the reinforcing value of food and weaken inhibitory control; however, whether it impacts upon the sensory representations …

Exciting breakthrough as Indian scientists 'turn plastic into petrol and diesel'

India will soon be able to convert its plastic wastes into high-grade petrol and diesel, thanks to a breakthrough by researchers at the Dehradun-based Indian Institute of Petroleum (IIP). The IIP, a constituent lab of the Council of Scientific and Industrial Research, has for the first time in the country …

Urinary phthalate metabolites are associated with decreased serum testosterone in men, women, and children from NHANES 2011–2012

There is evidence of declining trends in T levels among men in recent decades, as well as trends in related conditions at multiple life stages and in both sexes. There is also animal and limited human evidence that exposure to phthalates, chemicals found in plastics and personal care products, is …

Inhibitor of the Tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease

STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepr​opionicacid receptor (AMPAR) trafficking, as well as ERK1/2, p38, Fyn, and Pyk2 activity. STEP is overactive in several neuropsychiatric and neurodegenerative disorders, including Alzheimer's disease (AD). The increase in STEP activity likely disrupts synaptic function …

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