Order of the Supreme Court of India in the matter of Network of People Living With HIV/AIDS & Others Vs Union of India & Others dated 24/02/2025. The Supreme Court (SC), February 24, 2025 has directed all states to file their affidavits addressing concerns raised about antiretroviral therapy (ART) drugs …
The latest Ebola virus (EBOV) epidemic spread rapidly through Guinea, Sierra Leone, and Liberia, creating a global public health crisis and accelerating the assessment of experimental therapeutics and vaccines in clinical trials. One of those vaccines is based on recombinant vesicular stomatitis virus expressing the EBOV glycoprotein (VSV-EBOV), a live-attenuated …
A new drug compound could lead to a breakthrough in the fight against bovine spongiform encephalopathy, the incurable brain-wasting disease also known as mad cow disease, researchers said Wednesday. Scientists said the new antiprion drug, known as polythiophene, has proven highly effective in mice in blocking toxic, misfolded prions. Prions …
Doctors Should Avoid Prescribing Them As They Create Resistance To Condition Use of antibiotics to treat acne can have serious consequences, new research suggests. In India, dermatologists often prescribe antibiotics of all sorts to treat skin diseases. High-end antibiotics like azithromycin (normally used to treat sore throat and respiratory infections) …
Even as India-US trade (in both goods and services) has progressed towards the $100 billion mark, 2013-14 witnessed the emergence of a number of issues which adversely impacted the climate for bilateral trade and investment. Of these, none has been more contentious than the question of India’s IPR regime for …
A recombinant, replication-competent vesicular stomatitis virus-based vaccine expressing a surface glycoprotein of Zaire Ebolavirus (rVSV-ZEBOV) is a promising Ebola vaccine candidate. The researchers report the results of an interim analysis of a trial of rVSV-ZEBOV in Guinea, west Africa.
LONDON – Researchers in the United States trying to develop a vaccine against the deadly Middle East respiratory syndrome (MERS) virus say they have had early signs of success in animal experiments. Using a two-step approach in mice and rhesus macaques, scientists at the vaccine research center of the U.S. …
As much as 36 per cent of children with HIV have no access to medical care, a joint survey by Rwanda Network of People Living with HIV/AIDS, UNAIDS and Rwanda Biomedical Centre (RBC) shows. Vianney Byiringiro Rusisiro, a senior paediatric officer at RBC, said effective treatment of HIV-positive children is …
Some vaccines have been found to make some viruses more harmful via evolution, a new study has warned. The report, published in PLOS Biology, states that experiments with herpesvirus – a large family of DNA responsible for many diseases – shows some vaccines can only prove to make matters worse. …
The most advanced candidate vaccine against dengue viruses, called CYD-TDV, is progressing toward potential registration and review by the World Health Organization (WHO) in 2016. CYDTDV is a formulation of four chimeric yellow fever 17D vaccine viruses, each one engineered to express the surface envelope and prM (membrane) proteins from …
A candidate tetravalent dengue vaccine is being assessed in three clinical trials involving more than 35,000 children between the ages of 2 and 16 years in Asian–Pacific and Latin American countries. The researchers report the results of long-term follow-up interim analyses and integrated efficacy analyses.
The world's first malaria vaccine has cleared one of the final hurdles prior to being approved for use in Africa. The European Medicines Agency gave a positive scientific opinion after assessing its safety and effectiveness. It represents a 'green light' for the Mosquirix jab, developed by GlaxoSmithKline. The World Health …
The combination of daclatasvir, a hepatitis C virus (HCV) NS5A inhibitor, and the NS5B inhibitor sofosbuvir has shown efficacy in patients with HCV monoinfection. Data are lacking on the efficacy and safety of this combination in patients coinfected with human immunodeficiency virus type 1 (HIV-1). Original Source
Despite evidence that taking powerful anti-HIV drugs can help protect uninfected partners from contracting the virus that causes AIDS, the therapy is far from becoming routinely prescribed, scientists said Monday. The practice, known as pre-exposure prophylaxis, or PrEP, means that a healthy person who engages in sex with an HIV-positive …
Two new Ebola vaccine trials began on Wednesday with volunteers in Britain, France and Senegal getting "prime-boost" immunisations developed by Bavarian Nordic, GlaxoSmithKline and Johnson & Johnson. The mid-stage, or Phase II, trials are designed primarily to test the vaccines' safety, but will also assess whether they provoke an immune …
Expressing concern over expensive life-saving drugs and other essential medicines for major diseases, the Supreme Court on Wednesday asked the government to revisit its new National Pharmaceutical Pricing Policy, 2012, for fixing prices of essential medicines in the country and also the Drugs (Prices Control) Order, 2013 (DPCO 2013), notified …
Researchers at the University of Texas Medical Branch (UTMB), Galveston have discovered an inhalable vaccine that can protect rhesus macaque monkeys against severe illness and death when they were exposed to the Ebola virus. Rhesus Macaques are among the most widespread primates after humans and are the monkeys most widely …
A collaborative team from The University of Texas Medical Branch at Galveston and the National Institutes of Health have developed an inhalable vaccine that protects primates against Ebola. The findings were recently published in the Journal of Clinical Investigation. Previous studies with primates suggest that aerosols of most biothreat agents, …
Direct delivery of aerosolized vaccines to the respiratory mucosa elicits both systemic and mucosal responses. This vaccine strategy has not been tested for Ebola virus (EBOV) or other hemorrhagic fever viruses. Here, we examined the immunogenicity and protective efficacy of an aerosolized human parainfluenza virus type 3–vectored vaccine that expresses …
Clinical trials in India have again come under the regulatory scanner after the World Health Organisation (WHO) pointed out “critical“ lapses in trials of HIV drugs being conducted by a Chennaibased research organization. Following the enforcement by the United Nations' agency, the Indian regulator, Drugs Controller General of India (DCGI), …
The decreasing effectiveness of antimicrobial agents is a growing global public health concern. Low-income and middle-income countries are vulnerable to the loss of antimicrobial efficacy because of their high burden of infectious disease and the cost of treating resistant organisms. We aimed to assess if copayments in the public sector …
