Drugs

Order of the Supreme Court regarding ART drugs for people living with HIV/AIDS, 24/02/2025

Order of the Supreme Court of India in the matter of Network of People Living With HIV/AIDS & Others Vs Union of India & Others dated 24/02/2025. The Supreme Court (SC), February 24, 2025 has directed all states to file their affidavits addressing concerns raised about antiretroviral therapy (ART) drugs …

Dengue treatment inches closer with another antibody identified

The structure of another human antibody against the dengue virus has been determined, spurring the development of vaccines against the mosquito-borne disease that infects almost 400 million people a year. The dengue virus has four serotypes: DENV 1-4. Antibodies to two of the serotypes have been identified in recent studies. …

Injectable inactivated polio vaccine introduced

The vaccine, which will be injected at 14 weeks will provide the best protection against polio Immunisation: Bhutan introduced the injectable inactivated polio vaccine (IPV) in addition to the existing oral polio vaccine (OPV) into routine immunisation across the country on July 4. A dose of IPV has been introduced …

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, …

The efficacy and safety of the RTS,S/AS01 candidate malaria vaccine during 18 months of follow-up have been published previously. Herein, we report the final results from the same trial, including the efficacy of a booster dose.

The price of innovation: new estimates of drug development costs

The research and development costs of 68 randomly selected new drugs were obtained from a survey of 10 pharmaceutical firms. These data were used to estimate the average pre-tax cost of new drug development. The costs of compounds abandoned during testing were linked to the costs of compounds that obtained …

The potential impact of up-front drug sensitivity testing on India’s epidemic of multi-drug resistant tuberculosis

In India as elsewhere, multi-drug resistance (MDR) poses a serious challenge in the control of tuberculosis (TB). The End TB strategy, recently approved by the world health assembly, aims to reduce TB deaths by 95% and new cases by 90% between 2015 and 2035. A key pillar of this approach …

Tackling TB: It leaves a person with depression, no energy, recalls survivor

Of all the ills that kill the poor, none is as lethal as the bad govt: Experts Life came to a standstill when Marzia Dalal, a city-based corporate legal consultant and mother of two children, was diagnosed with Tuberculosis (TB) in her late 30s. She needed a stronger regimen to …

The 21st century Cures Act — Will it take us back in time?

In May 2015, the 21st Century Cures Act was introduced in the U.S. House of Representatives, with the goal of promoting the development and speeding the approval of new drugs and devices.1 Championed by the pharmaceutical, biotechnology, and device industries, the bill was approved unanimously (51 to 0) in committee …

Trans-Pacific trade pact triggers fears over drug prices

A new trade agreement being negotiated between 12 countries has come under fire from health campaigners who say it will push up drug prices and weaken health services.

China, US develop new MERS treatment

SHANGHAI - Chinese and American scientists have jointly developed a new antibody targeting the Middle East Respiratory Syndrome (MERS) virus, which has killed 16 people and landed 150 others in hospital. Fudan University, which worked with US National Institutes of Health to develop the antibody, said on Monday that tests …

Experimental Drug Regrows Damaged Body Tissue

An experimental drug treatment has opened a new door in regenerative medicine by helping lab mice regrow damaged liver, colon and bone marrow tissue, US researchers said Thursday. If the therapy is found to work in humans, scientists say it may save the lives of people who are critically ill …

Ghana Approves Trial of Ebola Vaccine

Accra — Despite protests from civil society, the Ghanaian Food and Drugs Authority (FDA) have given the nod for the commencement of Ebola vaccine trial in the country. The regulatory body in an official release signed by its chief executive, Hudu Mogtari communicated its decision to approve the trial of …

A Chinese Ebola Drug Raises Hopes, and Rancor

After a nurse who contracted Ebola in Sierra Leone was discharged Wednesday from a Rome hospital, a doctor there described the experimental treatments the patient had received as “absolutely miraculous.” They included MIL77, a product from China that was also given to a British Army nurse who recovered from Ebola …

Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multidrug resistance

The evolution of drug resistance is a major health threat. In chronic infections with rapidly mutating pathogens—including HIV, tuberculosis, and hepatitis B and C viruses—multidrug resistance can cause even aggressive combination drug treatment to fail. Oftentimes, individual drugs within a combination do not penetrate equally to all infected regions of …

Nigeria: New Study in Nigeria Finds One in 10 Malaria Drugs Is of Poor Quality

Abuja — A new research released recently has indicated that substandard medicines are more prevalent than fakes in the world's most malaria-burdened country, Nigeria. A rigorous analysis of more than 3,000 anti-malaria drugs purchased in Enugu, Nigeria found 9.3 per cent to be of poor quality, according to a new …

Nigeria: Vaccinologist Develops Immunogenic Experimental Ebola Vaccine

A vaccine developer from Nigeria, Dr Simon Agwale Friday in Paris, France, presented his progress report on Ebola vaccine saying that he "developed an EBOV candidate vaccine that is highly immunogenic in mice." Dr Agwale is among over 300 delegates drawn from forty-two countries to mark the International Conference on …

Researchers create new combination vaccine to fight Streptococcus A

Griffith University's Institute for Glycomics has developed a groundbreaking, combination vaccine that may finally beat Streptococcus A infections. Human trials are set to begin, early as next year, for the vaccine which combines the protein, SpyCEP, with a previously developed vaccine J8-DT. Infections caused by Streptococcus pyogenes are responsible for …

A multi-country study of the household willingness-to-pay for dengue vaccines: Household surveys in Vietnam, Thailand, and Colombia

The rise in dengue fever cases and the absence of dengue vaccines will likely cause governments to consider various types of effective means for controlling the disease. Given strong public interests in potential dengue vaccines, it is essential to understand the private economic benefits of dengue vaccines for accelerated introduction …

Thalidomide-induced teratogenesis: History and mechanisms

Nearly 60 years ago thalidomide was prescribed to treat morning sickness in pregnant women. What followed was the biggest man-made medical disaster ever, where over 10,000 children were born with a range of severe and debilitating malformations. Despite this, the drug is now used successfully to treat a range of …

Nigeria: 'One in 10 Malaria Drugs in Nigeria Is of Poor Quality'

Abuja — A new research released recently has indicated that substandard medicines are more prevalent than fake ones in world's most malaria-burdened country, Nigeria. A rigorous analysis of more than 3,000 antimalarials purchased in Enugu, Nigeria found 9.3% to be of poor quality, according to new research published in PLOS …

Why do some countries approve a cancer drug and others don’t?

The term drug reimbursement describes the policy system that determines whether or not a drug is entitled to reimbursement within the healthcare system. Countries make different decisions regarding which cancer treatments to routinely provide. As a result, depending on the cancer drug-indication and the country assessing it, the decision can …

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