Drugs

Order of the Supreme Court regarding ART drugs for people living with HIV/AIDS, 24/02/2025

Order of the Supreme Court of India in the matter of Network of People Living With HIV/AIDS & Others Vs Union of India & Others dated 24/02/2025. The Supreme Court (SC), February 24, 2025 has directed all states to file their affidavits addressing concerns raised about antiretroviral therapy (ART) drugs …

The draft Drugs and Cosmetics (Amendment) Rules, 2021

The Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homeopathy on 17th March 2021 has published the Draft Drugs and Cosmetics (Amendment) Rules, 2021 to further amend the Drugs and Cosmetics Rules, 1945. The Amendment is brought under Part XVI which deals with manufacturing for sale of ayurvedic, siddha …

Africa trade and Covid‑19: The supply chain dimension

Covid-19 has strengthened the case for developing intra-African regional value chains and unlocking the continent’s business potential through the African Continental Free Trade Area (AfCFTA). Covid‑19 has magnified Africa’s reliance on imported pharmaceuticals (both final and intermediate products) and amplified the urgency to build competitive, resilient and robust value chains …

Lack of efficacy of hydroxychloroquine in covid-19

Studies in mild-to-moderate cases as well as severe disease leave us still searching for a magic pill. (Editorial)

Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial

The objective of the study was to assess the efficacy and safety of hydroxychloroquine plus standard of care compared with standard of care alone in adults with coronavirus disease 2019 (covid-19).

Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data

The objective of the study wast to assess the effectiveness of hydroxychloroquine in patients admitted to hospital with coronavirus disease 2019 (covid-19) pneumonia who require oxygen.

Flooded by the torrent: the COVID-19 drug pipeline

The coronavirus disease 2019 (COVID-19) drug pipeline is not growing at quite the same speed as the pandemic. But its rate of expansion is nevertheless cause for pause. In the months since COVID-19 has spread, researchers have launched more than 180 clinical trials of everything from repurposed antivirals and immuno …

A trial of Lopinavir–Ritonavir in adults hospitalized with severe Covid-19

Researchers conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes the respiratory illness Covid-19, and an oxygen saturation (Sao2) of 94% or less while they were breathing ambient air or a ratio of the partial pressure of oxygen (Pao2) to the fraction of …

Coronavirus ourbreak: ICMR gets nod for ‘restricted use’ of two anti-HIV drugs

The Indian Council of Medical Research (ICMR) has obtained permission for “restricted use in public health emergency” of two second-line HIV medications for use against the novel coronavirus (nCoV). Top Health Ministry officials said these medications are to be used only in “vulnerable” cases, as they are not without side-effects. …

Predicting and designing therapeutics against the Nipah virus

Despite Nipah virus outbreaks having high mortality rates (>70% in Southeast Asia), there are no licensed drugs against it. In this study, we have considered all 9 Nipah proteins as potential therapeutic targets and computationally identified 4 putative peptide inhibitors (against G, F and M proteins) and 146 small molecule …

Question raised in Lok Sabha on Drug Resistant TB Cases, 06/12/2019

Question raised in Lok Sabha on Drug Resistant TB Cases, 06/12/2019. India has the largest number of individuals suffering from drug resistant TB. However, as per the latest global TB report, India ranks 38th in the number of MDR-TB patients per lakh population (9.6 per lakh population). The estimated number …

Outpatient antibiotic prescription rate and pattern in the private sector in India: Evidence from medical audit data

The key objective of this research was to generate new evidence on outpatient antibiotic prescription rate and patterns in the private sector in India. We used 12-month period (May 2013 to April 2014) medical audit dataset from IQVIA (formerly IMS Health). We coded the diagnosis provided in the medical audit …

Addressing poverty in India’s Revised National Tuberculosis Control Programme: are we failing to harness the opportunities?

The bi-directional relationship between poverty and tuberculosis (TB) is well established. Poverty aggravates material disadvantage, social exclusion, discrimination in participation across a wide range of socio-economic and behavioural activities along with undernutrition, overcrowding, lack of access to healthcare and other social determinants of health. Original Source

Registration of healthcare facilities mandatory

These rules aim to make available a database of clinical establishments which are authorised to function and thereby improve public health quality by eliminating quacks The Union Ministry of public health and family welfare on July 17 has issued the Clinical Establishments (Central Government) Third Amendment Rules 2019 and the …

Govt bans use of antibiotic Colistin in animal feed, poultry, aqua farms

According to the World Health Organisation (WHO), Colistin is a “reserve” antibiotic, which means it is supposed to be considered a “last-resort” option in treatment and used only in the most severe circumstances, when all other alternatives have failed. The Health Ministry has ordered a ban on using antibiotic Colistin …

The global threat of antimicrobial resistance and the challenges and needs of Developing Countries

Antimicrobial resistance (AMR) – in which a microorganism (such as a bacterium, virus, fungus or parasite) becomes resistant to an antimicrobial drug used to treat infections caused by it – is possibly the most serious public health threat of our time. Recognising the gravity of the problem, the international community …

Factors that get in the way of appropriate use of antimicrobial medicines in humans

In light of established principles and strategies for appropriate use of antimicrobial medicines, this paper examines studies on antimicrobial use trends across several countries in the Asia and Pacific regions. The author draws upon the outcomes of these studies, which look at prescribing patterns and consumer perceptions regarding antimicrobials, to …

Gilead's key drug used in HIV-related infection out of reach in developing countries'

MUMBAI: Pharma major Gilead Sciences has failed to deliver on promises to make an important drug available to patients suffering from a life-threatening HIV-related infection in certain developing countries including India, the medical humanitarian organisation Médecins Sans Frontières (MSF) said. Nearly one year ago, Gilead announced its ‘access initiative’ promising …

Drugs of 18 pharma firms found substandard since 2018

The Bureau of Pharma PSUs of India (BPPI), which implements the Centre’s flagship affordable medicine scheme PMBJP, has found 25 batches of drugs of 18 pharmaceutical companies to be of substandard quality since January 2018, according to an official document. While 17 out of the 18 companies are private, one …

Development of antiseptic adaptation and cross-adapatation in selected oral pathogens in vitro

There is evidence that pathogenic bacteria can adapt to antiseptics upon repeated exposure. More alarming is the concomitant increase in antibiotic resistance that has been described for some pathogens. Unfortunately, efects of adaptation and cross-adaptation are hardly known for oral pathogens, which are very frequently exposed to antiseptics. Therefore, this …

Association of maternal folate intake during pregnancy with infant asthma risk

Several studies assessed the association of maternal folate intake with infant asthma risk, but the fndings are controversial. We performed a meta-analysis to clarify the association between maternal folate intake and infant asthma risk. Original Source

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