Order of the National Green Tribunal in the matter of In Re: News Item titled "Nayar river is vanishing - a yatra reveals conservation goes beyond science and policy" appearing in ‘The Down To Earth’ dated 03.06.2025. The original application was registered suo-motu based on the news item titled "Nayar …
Despite dramatic progress against it, malaria still kills nearly half a million people a year, over 90 percent of them children in sub Saharan Africa. Almost all those deaths are preventable. A study published today in the American Journal of Tropical Medicine and Hygiene found that rapid-testing to distinguish malaria …
Mathabire, who works with Doctors Without Borders (MSF), won the HIV/TB research prize for her groundbreaking HIV/TB research on the use of a portable test for TB among severely ill HIV patients in Mozambique and Malawi clinics. The International Aids Society said the feasibility study provided strong evidence that an …
Coimbatore: The National Institute of Malaria Research (Nimr), a research institution of the Indian Council of Medical Research (Icmr), is planning to set up a malaria research centre on the Coimbatore Medical College (CMC) campus. A three-member team from Icmr will survey CMC premises on Wednesday to assess the feasibility …
Doctors report unusual symptomatic manifestations The Health Department has set up an expert committee to review the clinical management guidelines of dengue fever, after doctors from all government medical college hospitals in the State reported unusual symptomatic manifestations of dengue, rapid deterioration and death in many cases. The State has …
Scientists in The Gambia have come up with new innovative solutions to help stop the spread of malaria. They have built 800 homes to see if specific architectural design can prevent the disease from spreading.
Dr Rakesh K Mishra CCMB director said the finding will help in accelerating efforts for predictive and personalised genomic medicines. Hyderabad: CCMB’s finding on the South Asian population will throw light on diseases unknown to the world so far that were restricted to tribal populations and a few endogamous families. …
Basic ingredient of turmeric, in the form studied, is understood to be five times more ‘bioavailable’ in mice than in the regular one Curcumin, the basic ingredient of turmeric, when administered in a nanoparticle formulation has several favourable properties in the treatment of tuberculosis in mice, researchers have found. Prof. …
Transcription factor AP-1 plays a central role in HPV-mediated cervical carcinogenesis. AP-1 has also been implicated in chemo-radio-resistance but the mechanism(s) remained unexplored. In the present study, cervical cancer stem-like cells (CaCxSLCs) isolated and enriched from cervical cancer cell lines SiHa and C33a demonstrated an elevated AP-1 DNA-binding activity in …
ideR, an essential gene of Mycobacterium tuberculosis, is an attractive drug target as its conditional knockout displayed attenuated growth phenotype in vitro and in vivo. To the best of our knowledge, no inhibitors of IdeR are identified. We carried out virtual screening of NCI database against the IdeR DNA binding …
Diagnosis is complicated due to challenges associated with sample collection While detection of tuberculosis (TB) in children remains a challenge, it has now emerged that Multi-Drug Resistant (MDR) TB is higher among children than expected. This has been described as a “worrying trend” by the Union Health Ministry. As many …
Phase 2 of trials underway in Jalna on ‘friendly’ mosquitoes genetically modified to cause offspring to die. Next step? Limited tests in open field EVEN as urban local bodies gear up for annual monsoon outbreaks of dengue and malaria, inside a nondescript mesh cage at Jalna in central Maharashtra, trials …
The acidic glycoprotein chromogranin A (CHGA) is co-stored/co-secreted with catecholamines and crucial for secretory vesicle biogenesis in neuronal/neuroendocrine cells. CHGA is dysregulated in several cardiovascular diseases, but the underlying mechanisms are not well established. Here, we sought to identify common polymorphisms in the CHGA promoter and to explore the mechanistic …
Cathepsin L (CTSL) and B (CTSB) have a crucial role in extracellular matrix (ECM) degradation and tissue remodeling, which is a prominent feature of fibrogenesis. The aim of this study was to determine the role and clinical significance of these cathepsins in liver fibrosis. Original Source
Prolonged treatment of tuberculosis (TB) often leads to poor compliance, default and relapse, converting primary TB patients into category II TB (Cat IITB) cases, many of whom may convert to multi-drug resistant TB (MDR-TB). We have evaluated the immunotherapeutic potential of Mycobacterium indicus pranii (MIP) as an adjunct to Anti-Tubercular …
It has been hypothesized that some antibiotic resistance genes (ARGs) found in pathogenic bacteria derive from antibiotic-producing actinobacteria. Here we provide bioinformatic and experimental evidence supporting this hypothesis. We identify genes in proteobacteria, including some pathogens, that appear to be closely related to actinobacterial ARGs known to confer resistance against …
This is because both the vaccines undergoing trials will take several years to reach the counters. Though scientists at the ICGEB, International Centre for Genetic Engineering and Biotechnology, in the Capital, confirmed the first phase of the human clinical trials of Malaria vaccine and the pre-clinical research of 'Dengue' vaccine …
CYP1A1 gene is involved in estrogen metabolism, and previously, we have reported association of variant rs2606345 with altered anti-epileptic drugs (AED) response in North Indian women with epilepsy (WWE). The present study aims to replicate the pharmacogenetic association, perform functional characterization and study its distribution within ethnically diverse Indian population. …
Aims to accelerate early leads through product-development pipeline Developing home-grown vaccines to prevent dengue, human papillomavirus and pneumococcal infection, and biologics for diseases such as cancers and rheumatoid arthritis, are among the identified focus areas for the recently launched ₹1,500-crore National Biopharma Mission. The final decision on national identified priority …
Study Shows The Fruit's Extracts Can Inhibit Growth Of Malignant Cells Tomato extracts can inhibit the growth and malignant cloning of stomach cancer cells, according to a new study that paves the way for novel therapies to treat the deadly disease. Researchers analysed whole tomato extracts for their ability to …
The hybrid congener 3 derived from hydroxychalcone and pharmacophore oxypropanolamine for adrenergic receptor, along with its enantiomers 9a and 9b were selected from a series of compounds for detailed studies of their antidiabetic profile in sucrose-challenged, low-dosed, streptozotocin-induced diabetic rats and in db/db mice, and antidyslipidaemic profile in high fat …
