Research

R&D roadmap for green hydrogen ecosystem in India

The Ministry of New and Renewable Energy has published the R&D; Roadmap for Green Hydrogen Ecosystem in India. This document was published on 13th October, 2023. One of the central pillars of the National Green Hydrogen Mission is the establishment of a supportive research and innovation ecosystem for green hydrogen …

How much donor financing for health is channelled to global versus country-specific aid functions?

The slow global response to the Ebola crisis in west Africa suggests that important gaps exist in donor financing for key global functions, such as support for health research and development for diseases of poverty and strengthening of outbreak preparedness. In this Health Policy, we use the International Development Statistics …

Update on lifestyle determinants of postprandial triacylglycerolemia with emphasis on the Mediterranean lifestyle

This review updates the effect of lifestyle on plasma triacylglycerols (TAG) in the postprandial state, commonly reported as postprandial lipemia (PPL), an independent risk factor for cardiovascular diseases (CVD). Numerous studies have shown that Mediterranean diet may reduce PPL. However, most of these studies were focused on the type of …

The price of innovation: new estimates of drug development costs

The research and development costs of 68 randomly selected new drugs were obtained from a survey of 10 pharmaceutical firms. These data were used to estimate the average pre-tax cost of new drug development. The costs of compounds abandoned during testing were linked to the costs of compounds that obtained …

Laboratory rodent diets contain toxic levels of environmental contaminants: Implications for regulatory tests

The quality of diets in rodent feeding trials is crucial. We describe the contamination with environmental pollutants of 13 laboratory rodent diets from 5 continents. Measurements were performed using accredited methodologies. All diets were contaminated with pesticides (1-6 out of 262 measured), heavy metals (2-3 out of 4, mostly lead …

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

Traditional approaches for development of antibodies are poorly suited to combating the emergence of novel pathogens, as they require multiple steps of laborious optimization and process adaptation for clinical development. Here, we describe the simultaneous use of two state-of-the-art technologies to rapidly generate and validate antibodies against Middle East Respiratory …

Consuming high-protein soy snacks affects appetite control, satiety, and diet quality in young people and influences select aspects of mood and cognition

Data concerning the effects of afternoon snacking on ingestive behavior, mood, and cognition are limited. The purpose of this study was to compare 1088 kJ of high-protein (HP) or high-fat (HF) afternoon snacks vs. no snacking on appetite, food intake, mood, and cognition in adolescents.

Neutrino parameters and the N2-dominated scenario of leptogenesis

We briefly review the main aspects of leptogenesis, describing both the unflavoured and the flavoured versions of the N2-dominated scenario. A study of the success rates of both classes of models has been carried out. We comment on these results and discuss corrective effects to this simplest scenario. Focusing on …

Exposure to road traffic noise and behavioral problems in 7-year-old children: A cohort study

Exposure to traffic noise has been associated with adverse effects on neuropsychological outcomes in children, but findings with regard to behavioral problems are inconsistent. The researchers investigated whether residential road traffic noise exposure is associated with behavioral problems in 7 year old children.

Sacrificial amphiphiles: Eco-friendly chemical herders as oil spill mitigation chemicals

Crude oil spills are a major threat to marine biota and the environment. When light crude oil spills on water, it forms a thin layer that is difficult to clean by any methods of oil spill response. Under these circumstances, a special type of amphiphile termed as “chemical herder” is …

Targeting human transmission biology for malaria elimination

Malaria remains one of the leading causes of death worldwide, despite decades of public health efforts. The recent commitment by many endemic countries to eliminate malaria marks a shift away from programs aimed at controlling disease burden towards one that emphasizes reducing transmission of the most virulent human malaria parasite, …

A fat to forget: Trans fat consumption and memory

The researchers sought to assess the relation of dietary trans fatty acid (dTFA) consumption to word-memory. They analyzed cross-sectional data from the 1999-2005 UCSD Statin Study. Participants were 1018 adult men and non-procreative women age ≥20 without diagnosed diabetes, CVD, or extreme LDL-cholesterol. Primary analyses focused on men, as only …

EEG changes due to experimentally induced 3G mobile phone radiation

The aim of this study was to investigate whether a 15-minute placement of a 3G dialing mobile phone causes direct changes in EEG activity compared to the placement of a sham phone. Furthermore, it was investigated whether placement of the mobile phone on the ear or the heart would result …

A metabolic perspective of Peto's paradox and cancer

The frequency of cancer is postulated to be proportional to the number of cells an animal possesses, as each cell is similarly exposed to mutagens with every cell division. Larger animals result from more cell divisions with more mutagenic exposure, and hence are expected to have higher frequencies of cancer. …

Body composition during growth in children: limitations and perspectives of bioelectrical impedance analysis

There are a number of differences between the body composition of children and adults. Body composition measurements in children are inherently challenging, because of the rapid growth-related changes in height, weight, fat-free mass (FFM) and fat mass (FM), but they are fundamental for the quality of the clinical follow-up. All …

Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multidrug resistance

The evolution of drug resistance is a major health threat. In chronic infections with rapidly mutating pathogens—including HIV, tuberculosis, and hepatitis B and C viruses—multidrug resistance can cause even aggressive combination drug treatment to fail. Oftentimes, individual drugs within a combination do not penetrate equally to all infected regions of …

Screening currency notes for microbial pathogens and antibiotic resistance genes using a shotgun metagenomic approach

Fomites are a well-known source of microbial infections and previous studies have provided insights into the sojourning microbiome of fomites from various sources. Paper currency notes are one of the most commonly exchanged objects and its potential to transmit pathogenic organisms has been well recognized. Approaches to identify the microbiome …

Apollo plan on cheaper green energy seeks global backing

A plan for a new global research program aimed at driving down the costs of renewable energy more quickly has drawn serious interest from the world's leading economies, its proponents say. The Global Apollo Programme would be an internationally coordinated scheme of research and development focusing on electricity storage technology, …

Interaction between TIM-1 and NPC1 is important for cellular entry of Ebola virus

Multiple host molecules are known to be involved in the cellular entry of filoviruses, including Ebola virus (EBOV); T-cell immunoglobulin and mucin domain 1 (TIM-1) and Niemann-Pick C1 (NPC1) have been identified as attachment and fusion receptors, respectively. However, the molecular mechanisms underlying the entry process have not been fully …

Avian malaria in Hawaiian forest birds: infection and population impacts across species and elevations

Wildlife diseases can present significant threats to ecological systems and biological diversity, as well as domestic animal and human health. However, determining the dynamics of wildlife diseases and understanding the impact on host populations is a significant challenge. In Hawai‘i, there is ample circumstantial evidence that introduced avian malaria (Plasmodium …

Ancient DNA May Reveal How the Environment Impacted Past Human Populations

Ancient DNA may shed some light on how past environments impacted ancient human populations. Researchers have found that epigenetic marks on DNA can be detected in a large number of ancient human remains. "By looking at epigenetic marks, we can better understand what genes are expressed during a person's life …

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