Research

R&D roadmap for green hydrogen ecosystem in India

The Ministry of New and Renewable Energy has published the R&D; Roadmap for Green Hydrogen Ecosystem in India. This document was published on 13th October, 2023. One of the central pillars of the National Green Hydrogen Mission is the establishment of a supportive research and innovation ecosystem for green hydrogen …

The evidence base for fat guidelines: a balanced diet

Harcombe et al have conducted a systematic review and meta-analysis of randomised controlled trials (RCTs) that would have been available to the regulatory committees in the USA and the UK when guidelines on dietary fat intake were introduced (in 1977 and 1983, respectively). They found no evidence from RCTs to …

Changes in body mass index associated with head start participation

The goal of this study was to determine if Head Start participation is associated with healthy changes in BMI.

A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis

The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified ​IKK-ε and ​TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute inhibition of ​IKK-ε and ​TBK1 with ​amlexanox treatment increases ​cAMP levels in …

Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish

Here we demonstrate that bisphenol A (BPA) exposure during a time point analogous to the second trimester in humans has real and measurable effects on brain development and behavior. Furthermore, our study is the first, to our knowledge, to show that bisphenol S, a replacement used in BPA-free products, equally …

‘Indovation’ for affordable excellence

The Indian dream should not be about 'some Indians' doing well, but 'India' doing well. Making high technology work for the rich is easy. Can Indian scientists make high technology work for the poor? (Editorial) Original Source

Apoptosis in mice liver cells caused by Formalin–containing food: Normalization of HSP70 overexpression by chlorophyllin

Repeated exposure to formalin–containing foodstuff results in mice to overexpressing HSP70 (Heat Shock Protein, 70 kDa) and induction of apoptosis. This study tried to assess the efficacy of supplementation of chlorophyllin in inhibiting this induced apoptosis. Original Source

DBT and DST open access policy: policy on open access to DBT and DST funded research

Open access policy of the department of biotechnology (DBT) and department of science and technology (DST) has been finally approved and released with specific guidelines for the funded researchers and institutions. The policy assumes significance as the researchers and others will now have access to the DBT and DST funded …

Is the post-human a post-woman? Cyborgs, robots, artificial intelligence and the futures of gender: a case study

This study aims to shed light on the debate about the futures of gender, by taking into account its significance in the current development of Artificial Intelligence (AI), cyborg technologies and robotics. Its reflections are sustained by empirical data obtained between November 2010 and January 2011, when the author engaged …

The childhood obesity epidemic as a result of nongenetic evolution: The maternal resources hypothesis

Over the past century, socioenvironmental evolution (eg, reduced pathogenic load, decreased physical activity, and improved nutrition) led to cumulative increments in maternal energy resources (ie, body mass and adiposity) and decrements in energy expenditure and metabolic control. These decrements reduced the competition between maternal and fetal energy demands and increased …

A comparative encyclopedia of DNA elements in the mouse genome

The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium …

Proposed research plan for New Scientific Whale Research Program in the Antarctic Ocean (NEWREP-A)

Japan has unveiled a plan to kill 333 minke whales in the Southern Ocean next year as part of its push to resume whaling following a legal setback instigated by Australia. The plan, released by the Japanese government on Tuesday, sets out a 12-year program that would result in the …

Conservancy of mAb Epitopes in Ebolavirus Glycoproteins of previous and 2014 outbreaks

Several monoclonal antibodies (mAb) are being evaluated as treatment options for the current 2014 Ebola outbreak. But they were derived from and tested for protection against the older 1976 Mayinga or 1995 Kikwit Zaire Ebolaviruses (EBOV). The EBOV sequences reported for the current outbreak contain several mutations whose significance remained …

The path of least resistance: aggressive or moderate treatment?

The evolution of resistance to antimicrobial chemotherapy is a major and growing cause of human mortality and morbidity. Comparatively little attention has been paid to how different patient treatment strategies shape the evolution of resistance. In particular, it is not clear whether treating individual patients aggressively with high drug dosages …

Genetic diversity and association mapping of iron and zinc concentrations in chickpea (Cicer arietinum L.)

Chickpea (Cicer arietinum L.) is the world’s second most important pulse crop after common bean. Chickpea has historically been an important daily staple in the diet of millions of people, especially in the developing countries. Current chickpea breeding programs have mainly been directed toward high yield, biotic and abiotic stress …

Prenatal phthalate exposures and anogenital distance in Swedish boys

Phthalates are used as plasticizers in soft polyvinyl chloride (PVC) and in a large number of consumer products. Due to reported health risks, di-isononyl phthalate (DiNP) has been introduced as a replacement for diethyl hexyl phthalate (DEHP) in soft PVC. This raises concerns since animal data suggest that DiNP may …

A four-month Gatifloxacin-containing regimen for treating tuberculosis

Shortened antituberculosis treatment regimens are expected to improve patient adherence to treatment, thus favoring better case management and disease control and minimizing the risk of drug resistance.1-3 The first indication that fluoroquinolones had the potential to shorten tuberculosis treatment was from an observational study in India4 in which ethambutol was …

Shifts in species interactions due to the evolution of functional differences between endemics and non-endemics: An endemic syndrome hypothesis

Species ranges have been shifting since the Pleistocene, whereby fragmentation, isolation, and the subsequent reduction in gene flow have resulted in local adaptation of novel genotypes and the repeated evolution of endemic species. While there is a wide body of literature focused on understanding endemic species, very few studies empirically …

Holding thermal receipt paper and eating food after using hand sanitizer results in high serum bioactive and urine total levels of Bisphenol A (BPA)

Bisphenol A (BPA) is an endocrine disrupting environmental contaminant used in a wide variety of products, and BPA metabolites are found in almost everyone’s urine, suggesting widespread exposure from multiple sources. Regulatory agencies estimate that virtually all BPA exposure is from food and beverage packaging. However, free BPA is applied …

The high heritability of educational achievement reflects many genetically influenced traits, not just intelligence

Differences among children in educational achievement are highly heritable from the early school years until the end of compulsory education at age 16, when UK students are assessed nationwide with standard achievement tests [General Certificate of Secondary Education (GCSE)]. Genetic research has shown that intelligence makes a major contribution to …

Consumption of non–cow’s milk beverages and serum vitamin D levels in early childhood

Vitamin D fortification of non–cow's milk beverages is voluntary in North America. The effect of consuming non–cow's milk beverages on serum 25-hydroxyvitamin D levels in children is unclear. We studied the association between non–cow's milk consumption and 25-hydroxyvitamin D levels in healthy preschool-aged children. We also explored whether cow's milk …

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